Publikation: Amino acids form prenucleation clusters : ESI-MS as a fast detection method in comparison to analytical ultracentrifugation
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Electrospray ionisation mass spectrometry (ESI-MS) is a fast method which is able to provide molecular mass information with high precision. In this contribution, we show that prenucleation clusters—species recently found to play a pivotal role in crystallisation processes—are detected in addition to monomers by analytical ultracentrifugation (AUC) for the whole range of DL-amino acids, while higher oligomers are simultaneously observed in ESI-MS spectra. This suggests ESI-MS is a fast method to identify systems, which form prenucleation clusters. The occurrence of these clusters as relevant precursors in non-classical nucleation scenarios thus appears to be a more common phenomenon than so far assumed.
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KELLERMEIER, Matthias, Rose ROSENBERG, Adrian MOISE, Ulrike ANDERS, Michael PRZYBYLSKI, Helmut CÖLFEN, 2012. Amino acids form prenucleation clusters : ESI-MS as a fast detection method in comparison to analytical ultracentrifugation. In: Faraday Discussions. 2012, 159, pp. 23-45. ISSN 1359-6640. eISSN 1364-5498. Available under: doi: 10.1039/C2FD20060KBibTex
@article{Kellermeier2012Amino-22618, year={2012}, doi={10.1039/C2FD20060K}, title={Amino acids form prenucleation clusters : ESI-MS as a fast detection method in comparison to analytical ultracentrifugation}, volume={159}, issn={1359-6640}, journal={Faraday Discussions}, pages={23--45}, author={Kellermeier, Matthias and Rosenberg, Rose and Moise, Adrian and Anders, Ulrike and Przybylski, Michael and Cölfen, Helmut} }
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