Amino acids form prenucleation clusters : ESI-MS as a fast detection method in comparison to analytical ultracentrifugation

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Faraday Discussions. 2012, 159, pp. 23-45. ISSN 1359-6640. eISSN 1364-5498. Available under: doi: 10.1039/C2FD20060K
Zusammenfassung

Electrospray ionisation mass spectrometry (ESI-MS) is a fast method which is able to provide molecular mass information with high precision. In this contribution, we show that prenucleation clusters—species recently found to play a pivotal role in crystallisation processes—are detected in addition to monomers by analytical ultracentrifugation (AUC) for the whole range of DL-amino acids, while higher oligomers are simultaneously observed in ESI-MS spectra. This suggests ESI-MS is a fast method to identify systems, which form prenucleation clusters. The occurrence of these clusters as relevant precursors in non-classical nucleation scenarios thus appears to be a more common phenomenon than so far assumed.

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ISO 690KELLERMEIER, Matthias, Rose ROSENBERG, Adrian MOISE, Ulrike ANDERS, Michael PRZYBYLSKI, Helmut CÖLFEN, 2012. Amino acids form prenucleation clusters : ESI-MS as a fast detection method in comparison to analytical ultracentrifugation. In: Faraday Discussions. 2012, 159, pp. 23-45. ISSN 1359-6640. eISSN 1364-5498. Available under: doi: 10.1039/C2FD20060K
BibTex
@article{Kellermeier2012Amino-22618,
  year={2012},
  doi={10.1039/C2FD20060K},
  title={Amino acids form prenucleation clusters : ESI-MS as a fast detection method in comparison to analytical ultracentrifugation},
  volume={159},
  issn={1359-6640},
  journal={Faraday Discussions},
  pages={23--45},
  author={Kellermeier, Matthias and Rosenberg, Rose and Moise, Adrian and Anders, Ulrike and Przybylski, Michael and Cölfen, Helmut}
}
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