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Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway

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2012

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Riclea, Ramona
Aigle, Bertrand
Leblond, Pierre
Schoenian, Ilka
Dickschat, Jeroen S.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-208425
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https://doi.org/10.1002/cbic.201200260
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ChemBioChem. 2012, 13(11), pp. 1635-1644. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201200260

Zusammenfassung

The volatiles released by several streptomycetes were collected by using a closed-loop stripping apparatus (CLSA) and analysed by GC-MS. The obtained headspace extracts of various species contained blastmycinone, a known degradation product of the fungicidal antibiotic, antimycin A(3b), and several unknown derivatives. The suggested structures of these compounds, based on their mass spectra and GC retention indices, were confirmed by comparison to synthetic reference samples. Additional compounds found in the headspace extracts were butenolides formed from the blastmycinones by elimination of the carboxylic acid moiety. Analysis of a gene knockout mutant in the antimycin biosynthetic gene cluster demonstrated that all blastmycinones and butenolides are formed via the antimycin biosynthetic pathway. The structural variation of the blastmycinones identified here is much larger than within the known antimycins, thus suggesting that several antimycin derivatives remain to be discovered.

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570 Biowissenschaften, Biologie

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ISO 690RICLEA, Ramona, Bertrand AIGLE, Pierre LEBLOND, Ilka SCHOENIAN, Dieter SPITELLER, Jeroen S. DICKSCHAT, 2012. Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway. In: ChemBioChem. 2012, 13(11), pp. 1635-1644. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201200260
BibTex
@article{Riclea2012-07-23Volat-20842,
  year={2012},
  doi={10.1002/cbic.201200260},
  title={Volatile Lactones from Streptomycetes Arise via the Antimycin Biosynthetic Pathway},
  number={11},
  volume={13},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1635--1644},
  author={Riclea, Ramona and Aigle, Bertrand and Leblond, Pierre and Schoenian, Ilka and Spiteller, Dieter and Dickschat, Jeroen S.}
}
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