Mass spectrometric analysis of sulfur mustard-induced biomolecular adducts : Are DNA adducts suitable biomarkers of exposure?

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Toxicology Letters. 2018, 293, pp. 21-30. ISSN 0378-4274. eISSN 1879-3169. Available under: doi: 10.1016/j.toxlet.2017.12.014
Zusammenfassung

The bi-functional chemical warfare agent sulfur mustard (SM), whose release in asymmetric conflicts or terrorist attacks represents a realistic threat, induces several kinds of biomolecular adducts, including highly toxic DNA adducts. Isotope dilution liquid chromatographic tandem mass spectrometry (ID-LC-MS/MS) is considered the gold standard for highly accurate, precise, specific and sensitive quantification of DNA adducts in general. Recently, a number of LC-MS/MS approaches have been established to analyze SM-induced protein and DNA adducts in cell culture and rodent animal models. As DNA adducts are mechanism-based biomarkers for SM exposure, results from such studies provide a deeper understanding of the etiology of SM-induced pathologies, especially of long-term effects such as cancer formation. As a result, medical treatment of SM-exposed individuals might be improved. Yet, despite the progress that has been made during the last years, there is still a need for advanced methods of ID-LC-MS/MS for the detection and quantitation of SM adducts.

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570 Biowissenschaften, Biologie
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Sulfur mustard, DNA damage, LC-MS/MS, Mass spectrometry, Biomarkers, Chemical warfare agents, Technical review
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ISO 690ZUBEL, Tabea, Alexander BÜRKLE, Aswin MANGERICH, 2018. Mass spectrometric analysis of sulfur mustard-induced biomolecular adducts : Are DNA adducts suitable biomarkers of exposure?. In: Toxicology Letters. 2018, 293, pp. 21-30. ISSN 0378-4274. eISSN 1879-3169. Available under: doi: 10.1016/j.toxlet.2017.12.014
BibTex
@article{Zubel2018-09-01spect-42546,
  year={2018},
  doi={10.1016/j.toxlet.2017.12.014},
  title={Mass spectrometric analysis of sulfur mustard-induced biomolecular adducts : Are DNA adducts suitable biomarkers of exposure?},
  volume={293},
  issn={0378-4274},
  journal={Toxicology Letters},
  pages={21--30},
  author={Zubel, Tabea and Bürkle, Alexander and Mangerich, Aswin}
}
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    <dcterms:abstract xml:lang="eng">The bi-functional chemical warfare agent sulfur mustard (SM), whose release in asymmetric conflicts or terrorist attacks represents a realistic threat, induces several kinds of biomolecular adducts, including highly toxic DNA adducts. Isotope dilution liquid chromatographic tandem mass spectrometry (ID-LC-MS/MS) is considered the gold standard for highly accurate, precise, specific and sensitive quantification of DNA adducts in general. Recently, a number of LC-MS/MS approaches have been established to analyze SM-induced protein and DNA adducts in cell culture and rodent animal models. As DNA adducts are mechanism-based biomarkers for SM exposure, results from such studies provide a deeper understanding of the etiology of SM-induced pathologies, especially of long-term effects such as cancer formation. As a result, medical treatment of SM-exposed individuals might be improved. Yet, despite the progress that has been made during the last years, there is still a need for advanced methods of ID-LC-MS/MS for the detection and quantitation of SM adducts.</dcterms:abstract>
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