Publikation: The evolution and function of the Pax/Six regulatory network in sponges
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2013
Autor:innen
Rivera, Ajna
Winters, Ian
Rued, A.
Posfai, Dora
Cieniewicz, Brandon
Cameron, Kimberly
Gentile, Lisa
Hill, April
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Evolution & Development. Wiley. 2013, 15(3), pp. 186-196. ISSN 1520-541X. eISSN 1525-142X. Available under: doi: 10.1111/ede.12032
Zusammenfassung
Examining the origins of highly conserved gene regulatory networks (GRNs) will inform our understanding of the evolution of animal body plans. Sponges are believed to be the most ancient extant metazoan lineage, and as such, hold clues about the evolution of genetic programs deployed in animal development. We used the emerging freshwater sponge model, Ephydatia muelleri, to study the evolutionary origins of the Pax/Six/Eya/Dac (PSED) GRN. Orthologs to Pax and Six family members are present in E. muelleri and are expressed in endothelial cells lining the canal system as well as cells in the choanoderm. Knockdown of EmPaxB and EmSix1/2 by RNAi resulted in defects to the canal systems. We further show that PaxB may be in a regulatory relationship with Six1/2 in E. muelleri, thus demonstrating that a component of the PSED network was present early in metazoan evolution.
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RIVERA, Ajna, Ian WINTERS, A. RUED, Serena DING, Dora POSFAI, Brandon CIENIEWICZ, Kimberly CAMERON, Lisa GENTILE, April HILL, 2013. The evolution and function of the Pax/Six regulatory network in sponges. In: Evolution & Development. Wiley. 2013, 15(3), pp. 186-196. ISSN 1520-541X. eISSN 1525-142X. Available under: doi: 10.1111/ede.12032BibTex
@article{Rivera2013-05evolu-54666,
year={2013},
doi={10.1111/ede.12032},
title={The evolution and function of the Pax/Six regulatory network in sponges},
number={3},
volume={15},
issn={1520-541X},
journal={Evolution & Development},
pages={186--196},
author={Rivera, Ajna and Winters, Ian and Rued, A. and Ding, Serena and Posfai, Dora and Cieniewicz, Brandon and Cameron, Kimberly and Gentile, Lisa and Hill, April}
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<dcterms:abstract xml:lang="eng">Examining the origins of highly conserved gene regulatory networks (GRNs) will inform our understanding of the evolution of animal body plans. Sponges are believed to be the most ancient extant metazoan lineage, and as such, hold clues about the evolution of genetic programs deployed in animal development. We used the emerging freshwater sponge model, Ephydatia muelleri, to study the evolutionary origins of the Pax/Six/Eya/Dac (PSED) GRN. Orthologs to Pax and Six family members are present in E. muelleri and are expressed in endothelial cells lining the canal system as well as cells in the choanoderm. Knockdown of EmPaxB and EmSix1/2 by RNAi resulted in defects to the canal systems. We further show that PaxB may be in a regulatory relationship with Six1/2 in E. muelleri, thus demonstrating that a component of the PSED network was present early in metazoan evolution.</dcterms:abstract>
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