Publikation: Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology
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2003
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Seminars in Immunology. 2003, 15(3), pp. 167-176. ISSN 1044-5323. Available under: doi: 10.1016/S1044-5323(03)00035-6
Zusammenfassung
Members of the tumor necrosis factor (TNF) superfamily are crucially involved in the regulation of T cell activation, homeostasis and cytotoxicity. In particular, Fas ligand (FasL), expressed by activated T lymphocytes, induces cell-mediated cytotoxicity and may also be responsible for apoptotic suicide. Tight regulation of this death-inducing ligand is a prerequisite for proper immune defense and homeostasis. In this review, we will discuss various aspects of FasL regulation in cell-mediated cytotoxicity, immune homeostasis and the immunopathology of diseases.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Apoptosis, Death receptors, Disease, Lymphocyte, Transcription
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BRUNNER, Thomas, Christoph WASEM, Ralph TORGLER, Igor CIMA, Sabine JAKOB, Nadia CORAZZA, 2003. Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology. In: Seminars in Immunology. 2003, 15(3), pp. 167-176. ISSN 1044-5323. Available under: doi: 10.1016/S1044-5323(03)00035-6BibTex
@article{Brunner2003CD95A-14354,
year={2003},
doi={10.1016/S1044-5323(03)00035-6},
title={Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology},
number={3},
volume={15},
issn={1044-5323},
journal={Seminars in Immunology},
pages={167--176},
author={Brunner, Thomas and Wasem, Christoph and Torgler, Ralph and Cima, Igor and Jakob, Sabine and Corazza, Nadia}
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