Publikation: Cell death pathology : Cross-talk with autophagy and its clinical implications
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2011
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Core Facility der Universität Konstanz
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Published
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Biochemical and Biophysical Research Communications. Elsevier. 2011, 414(2), pp. 277-281. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1016/j.bbrc.2011.09.080
Zusammenfassung
Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, "autophagic cell death". Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Autophagy, Programmed cell death, Apoptosis, Cancer, p53
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ISO 690
AMELIO, Ivano, Gerry MELINO, Richard A. KNIGHT, 2011. Cell death pathology : Cross-talk with autophagy and its clinical implications. In: Biochemical and Biophysical Research Communications. Elsevier. 2011, 414(2), pp. 277-281. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1016/j.bbrc.2011.09.080BibTex
@article{Amelio2011-10-22death-57197,
year={2011},
doi={10.1016/j.bbrc.2011.09.080},
title={Cell death pathology : Cross-talk with autophagy and its clinical implications},
number={2},
volume={414},
issn={0006-291X},
journal={Biochemical and Biophysical Research Communications},
pages={277--281},
author={Amelio, Ivano and Melino, Gerry and Knight, Richard A.}
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<dcterms:abstract xml:lang="eng">Autophagy is a self-digesting mechanism that cells adopt to respond to stressful stimuli. Morphologically, cells dying by autophagy show multiple cytoplasmic double-membraned vacuoles, and, if prolonged, autophagy can lead to cell death, "autophagic cell death". Thus, autophagy can act both as a temporary protective mechanism during a brief stressful episode and be a mode of cell death in its own right. In this mini-review we focus on recent knowledge concerning the connection between autophagy and programmed cell death, evaluating their possible implications for therapy in pathologies like cancer and neurodegeneration.</dcterms:abstract>
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