Publikation:

Chemical genetics : tailoring tools for cell biology

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mayer_140524.pdf
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2003

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http://nbn-resolving.de/urn:nbn:de:bsz:352-140524
DOI (zitierfähiger Link)
https://doi.org/10.1016/S0962-8924(03)00077-1
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Open Access-Veröffentlichung
Open Access Green

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Biologie: Publikationen
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Published

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Trends in Cell Biology. 2003, 13(5), pp. 270-277. ISSN 0962-8924. Available under: doi: 10.1016/S0962-8924(03)00077-1

Zusammenfassung

Chemical genetics is a research approach that uses small molecules as probes to study protein functions in cells or whole organisms. Here, I review the parallels between classical genetic and chemical-genetic approaches and discuss the merits of small molecules to dissect dynamic cellular processes. I then consider the pros and cons of different screening approaches and specify strategies aimed at identifying and validating cellular target proteins. Finally, I highlight the impact of chemical genetics on our current understanding of cell biology and its potential for the future.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

small molecule, Eg5, Kinesin, Chemical Biology

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undefined / . - undefined, undefined

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ISO 690MAYER, Thomas U., 2003. Chemical genetics : tailoring tools for cell biology. In: Trends in Cell Biology. 2003, 13(5), pp. 270-277. ISSN 0962-8924. Available under: doi: 10.1016/S0962-8924(03)00077-1
BibTex
@article{Mayer2003Chemi-14052,
  year={2003},
  doi={10.1016/S0962-8924(03)00077-1},
  title={Chemical genetics : tailoring tools for cell biology},
  number={5},
  volume={13},
  issn={0962-8924},
  journal={Trends in Cell Biology},
  pages={270--277},
  author={Mayer, Thomas U.}
}
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