@article{LeiWee2019bidir-53500,
  year={2019},
  doi={10.7554/eLife.43775.001},
  title={A bidirectional network for appetite control in larval zebrafish},
  number={8},
  journal={eLife},
  author={Lei Wee, Caroline and Yue Song, Erin and Evan Johnson, Robert and Ailani, Deepak and Randlett, Owen and Kim, Ji-Yoon and Nikitchenko, Maxim and Bahl, Armin and Yang, Chao-Tsung},
  note={Article Number: e43775}
}

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/53500">
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-04-27T09:34:07Z</dcterms:available>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Ailani, Deepak</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-04-27T09:34:07Z</dc:date>
    <dc:creator>Yang, Chao-Tsung</dc:creator>
    <dcterms:abstract xml:lang="eng">Medial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored. Here we report that, in larval zebrafish, primarily serotonergic neurons of the ventromedial caudal hypothalamus (cH) become increasingly active during food deprivation, whereas activity in the lateral hypothalamus (LH) is reduced. Exposure to food sensory and consummatory cues reverses the activity patterns of these two nuclei, consistent with their representation of opposing internal hunger states. Baseline activity is restored as food-deprived animals return to satiety via voracious feeding. The antagonistic relationship and functional importance of cH and LH activity patterns were confirmed by targeted stimulation and ablation of cH neurons. Collectively, the data allow us to propose a model in which these hypothalamic nuclei regulate different phases of hunger and satiety and coordinate energy balance via antagonistic control of distinct behavioral outputs.</dcterms:abstract>
    <dcterms:title>A bidirectional network for appetite control in larval zebrafish</dcterms:title>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/53500/3/Wee_2-10a6b3ypkds7m5.pdf"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/53500/3/Wee_2-10a6b3ypkds7m5.pdf"/>
    <dc:contributor>Lei Wee, Caroline</dc:contributor>
    <dc:creator>Lei Wee, Caroline</dc:creator>
    <dc:contributor>Randlett, Owen</dc:contributor>
    <dc:creator>Bahl, Armin</dc:creator>
    <dcterms:issued>2019</dcterms:issued>
    <dc:creator>Ailani, Deepak</dc:creator>
    <dc:contributor>Evan Johnson, Robert</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Yue Song, Erin</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Yue Song, Erin</dc:contributor>
    <dc:contributor>Bahl, Armin</dc:contributor>
    <dc:contributor>Nikitchenko, Maxim</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Kim, Ji-Yoon</dc:creator>
    <dc:contributor>Kim, Ji-Yoon</dc:contributor>
    <dc:contributor>Yang, Chao-Tsung</dc:contributor>
    <dc:creator>Randlett, Owen</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/53500"/>
    <dc:creator>Evan Johnson, Robert</dc:creator>
    <dc:creator>Nikitchenko, Maxim</dc:creator>
  </rdf:Description>
</rdf:RDF>