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Facile Synthesis of Fluorinated Benzofuro- and Benzothieno[2,3-b]pyridines, α-Carbolines and Nucleosides Containing the α-Carboline Framework

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2009

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Iaroshenko, Viktor O.
Zhang, Biao
Volochnyuk, Dmitriy
Sosnovskikh, Vyacheslav

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https://doi.org/10.1055/s-0029-1217396
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Synthesis. Georg Thieme Verlag. 2009, 2009(14), pp. 2393-2402. ISSN 0039-7881. eISSN 1437-210X. Available under: doi: 10.1055/s-0029-1217396

Zusammenfassung

Fluorinated benzofuro[2,3-b]pyridines, benzo­thieno[2,3-b]pyridines and 9H-pyrido[2,3-b]indoles (α-carbolines) were synthesized via regiospecific pyridine core annulation of a number of fluoro-containing 1,3-CCC-dielectrophiles to benzofuran-2-amine, benzothiophen-2-amine and 1H-indol-2-amine. Based on the 2,4-bis(trifluoromethyl)-9H-pyrido[2,3-b]indole thus synthesized, the preparative approach towards a set of nucleosides and nucleoside mimetics bearing the α-carboline framework was elaborated.

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540 Chemie

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ISO 690IAROSHENKO, Viktor O., Yan WANG, Biao ZHANG, Dmitriy VOLOCHNYUK, Vyacheslav SOSNOVSKIKH, 2009. Facile Synthesis of Fluorinated Benzofuro- and Benzothieno[2,3-b]pyridines, α-Carbolines and Nucleosides Containing the α-Carboline Framework. In: Synthesis. Georg Thieme Verlag. 2009, 2009(14), pp. 2393-2402. ISSN 0039-7881. eISSN 1437-210X. Available under: doi: 10.1055/s-0029-1217396
BibTex
@article{Iaroshenko2009Facil-58009,
  year={2009},
  doi={10.1055/s-0029-1217396},
  title={Facile Synthesis of Fluorinated Benzofuro- and Benzothieno[2,3-b]pyridines, α-Carbolines and Nucleosides Containing the α-Carboline Framework},
  number={14},
  volume={2009},
  issn={0039-7881},
  journal={Synthesis},
  pages={2393--2402},
  author={Iaroshenko, Viktor O. and Wang, Yan and Zhang, Biao and Volochnyuk, Dmitriy and Sosnovskikh, Vyacheslav}
}
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