Publikation:

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Lade...
Vorschaubild

Dateien

Schoissengeier_2-zg840ya0c9vp8.pdf
Schoissengeier_2-zg840ya0c9vp8.pdfGröße: 2.67 MBDownloads: 19

Datum

2024

Autor:innen

Schoissengeier, Vanessa
Maqboul, Lina
Weber, Daniela
Grune, Tilman
Franceschi, Claudio
Capri, Miriam
Bernhard, Jürgen
Wagner, Karl-Heinz
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

Angaben zur Forschungsförderung

Austrian Science Fund (FWF): P 32303
European Union (EU): 200880

Projekt

Open Access-Veröffentlichung
Open Access Gold
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

iScience. Elsevier. 2024, 27(7), S. 110234-110234. ISSN 2589-0042. Verfügbar unter: doi: 10.1016/j.isci.2024.110234

Zusammenfassung

Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690SCHOISSENGEIER, Vanessa, Lina MAQBOUL, Daniela WEBER, Tilman GRUNE, Alexander BÜRKLE, Maria MORENO-VILLANUEVA, Claudio FRANCESCHI, Miriam CAPRI, Jürgen BERNHARD, Karl-Heinz WAGNER, 2024. Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort. In: iScience. Elsevier. 2024, 27(7), S. 110234-110234. ISSN 2589-0042. Verfügbar unter: doi: 10.1016/j.isci.2024.110234
BibTex
@article{Schoissengeier2024-07Assoc-70571,
  year={2024},
  doi={10.1016/j.isci.2024.110234},
  title={Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort},
  number={7},
  volume={27},
  issn={2589-0042},
  journal={iScience},
  pages={110234--110234},
  author={Schoissengeier, Vanessa and Maqboul, Lina and Weber, Daniela and Grune, Tilman and Bürkle, Alexander and Moreno-Villanueva, Maria and Franceschi, Claudio and Capri, Miriam and Bernhard, Jürgen and Wagner, Karl-Heinz},
  note={Article Number: 110234}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/70571">
    <dc:creator>Franceschi, Claudio</dc:creator>
    <dc:contributor>Weber, Daniela</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/70571/1/Schoissengeier_2-zg840ya0c9vp8.pdf"/>
    <dc:contributor>Franceschi, Claudio</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:contributor>Moreno-Villanueva, Maria</dc:contributor>
    <dc:contributor>Bernhard, Jürgen</dc:contributor>
    <dc:creator>Schoissengeier, Vanessa</dc:creator>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <dc:contributor>Maqboul, Lina</dc:contributor>
    <dcterms:title>Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort</dcterms:title>
    <dc:contributor>Grune, Tilman</dc:contributor>
    <dcterms:issued>2024-07</dcterms:issued>
    <dc:creator>Moreno-Villanueva, Maria</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2024-08-09T11:50:26Z</dc:date>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2024-08-09T11:50:26Z</dcterms:available>
    <dc:contributor>Wagner, Karl-Heinz</dc:contributor>
    <dcterms:abstract>Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since
this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.</dcterms:abstract>
    <dc:creator>Wagner, Karl-Heinz</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/70571/1/Schoissengeier_2-zg840ya0c9vp8.pdf"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Schoissengeier, Vanessa</dc:contributor>
    <dc:creator>Weber, Daniela</dc:creator>
    <dc:creator>Maqboul, Lina</dc:creator>
    <dc:creator>Bernhard, Jürgen</dc:creator>
    <dc:creator>Grune, Tilman</dc:creator>
    <dc:creator>Capri, Miriam</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/70571"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Capri, Miriam</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen