Publikation:

Serine and glycine metabolism in cancer

Vorschaubild

Dateien

Amelio_2-z3qkaotm878n6.pdf
Amelio_2-z3qkaotm878n6.pdfGröße: 419.21 KBDownloads: 107

Datum

2014

Autor:innen

Cutruzzolá, Francesca
Antonov, Alexey
Agostini, Massimiliano
Melino, Gerry

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-z3qkaotm878n6
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.tibs.2014.02.004
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Attribution-NonCommercial-NoDerivs 3.0 Unported

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Hybrid

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Trends in biochemical sciences. Cell Press. 2014, 39(4), pp. 191-198. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2014.02.004

Zusammenfassung

Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

cancer metabolism, serine, glycine, one-carbon metabolism, folate

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690AMELIO, Ivano, Francesca CUTRUZZOLÁ, Alexey ANTONOV, Massimiliano AGOSTINI, Gerry MELINO, 2014. Serine and glycine metabolism in cancer. In: Trends in biochemical sciences. Cell Press. 2014, 39(4), pp. 191-198. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2014.02.004
BibTex
@article{Amelio2014Serin-57085,
  year={2014},
  doi={10.1016/j.tibs.2014.02.004},
  title={Serine and glycine metabolism in cancer},
  number={4},
  volume={39},
  issn={0968-0004},
  journal={Trends in biochemical sciences},
  pages={191--198},
  author={Amelio, Ivano and Cutruzzolá, Francesca and Antonov, Alexey and Agostini, Massimiliano and Melino, Gerry}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/57085">
    <dcterms:title>Serine and glycine metabolism in cancer</dcterms:title>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57085"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:issued>2014</dcterms:issued>
    <dc:creator>Melino, Gerry</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57085/1/Amelio_2-z3qkaotm878n6.pdf"/>
    <dcterms:abstract xml:lang="eng">Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.</dcterms:abstract>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Cutruzzolá, Francesca</dc:creator>
    <dc:contributor>Antonov, Alexey</dc:contributor>
    <dc:contributor>Cutruzzolá, Francesca</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Agostini, Massimiliano</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57085/1/Amelio_2-z3qkaotm878n6.pdf"/>
    <dc:creator>Antonov, Alexey</dc:creator>
    <dc:rights>Attribution-NonCommercial-NoDerivs 3.0 Unported</dc:rights>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Melino, Gerry</dc:contributor>
    <dc:contributor>Amelio, Ivano</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-30T09:40:37Z</dcterms:available>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/3.0/"/>
    <dc:creator>Amelio, Ivano</dc:creator>
    <dc:contributor>Agostini, Massimiliano</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-30T09:40:37Z</dc:date>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Ja
Diese Publikation teilen