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Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC)

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Neuhaus_0-326434.pdf
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2016

Autor:innen

Neuhaus, Klaus
Landstorfer, Richard
Fellner, Lea
Schafferhans, Andrea
Goldberg, Tatyana
Marx, Harald
Ozoline, Olga N.
Scherer, Siegfried
et al.

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Published

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BMC Genomics. 2016, 17(1), 133. eISSN 1471-2164. Available under: doi: 10.1186/s12864-016-2456-1

Zusammenfassung

Genomes of E. coli, including that of the human pathogen Escherichia coli O157:H7 (EHEC) EDL933, still harbor undetected protein-coding genes which, apparently, have escaped annotation due to their small size and non-essential function. To find such genes, global gene expression of EHEC EDL933 was examined, using strand-specific RNAseq (transcriptome), ribosomal footprinting (translatome) and mass spectrometry (proteome).

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570 Biowissenschaften, Biologie

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ISO 690NEUHAUS, Klaus, Richard LANDSTORFER, Lea FELLNER, Svenja SIMON, Andrea SCHAFFERHANS, Tatyana GOLDBERG, Harald MARX, Olga N. OZOLINE, Daniel A. KEIM, Siegfried SCHERER, 2016. Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC). In: BMC Genomics. 2016, 17(1), 133. eISSN 1471-2164. Available under: doi: 10.1186/s12864-016-2456-1
BibTex
@article{Neuhaus2016Trans-33899,
  year={2016},
  doi={10.1186/s12864-016-2456-1},
  title={Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC)},
  number={1},
  volume={17},
  journal={BMC Genomics},
  author={Neuhaus, Klaus and Landstorfer, Richard and Fellner, Lea and Simon, Svenja and Schafferhans, Andrea and Goldberg, Tatyana and Marx, Harald and Ozoline, Olga N. and Keim, Daniel A. and Scherer, Siegfried},
  note={Article Number: 133}
}
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