Publikation:

The Human Toxome Project

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Datum

2015

Autor:innen

Bouhifd, Mounir
Andersen, Melvin E.
Baghdikian, Christina
Boekelheide, Kim
Crofton, Kevin M.
Fornace Jr., Albert J.
Kleensang, Andre
Li, Henghong
Livi, Carolina
Maertens, Alexandra
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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-289871
DOI (zitierfähiger Link)
https://doi.org/10.14573/altex.1502091
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CC BY 4.0

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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
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Published

Erschienen in

ALTEX : Alternatives to Animal Experimentation. 2015, 32(2), pp. 112-124. ISSN 0946-7785. eISSN 1868-8551. Available under: doi: 10.14573/altex.1502091

Zusammenfassung

The Human Toxome Project, funded as an NIH Transformative Research grant 2011-2016, is focused on developing the concepts and the means for deducing, validating and sharing molecular pathways of toxicity (PoT). Using the test case of estrogenic endocrine disruption, the responses of MCF-7 human breast cancer cells are being phenotyped by transcriptomics and mass-spectrometry-based metabolomics. The bioinformatics tools for PoT deduction represent a core deliverable. A number of challenges for quality and standardization of cell systems, omics technologies and bioinformatics are being addressed. In parallel, concepts for annotation, validation and sharing of PoT information, as well as their link to adverse outcomes, are being developed. A reasonably comprehensive public database of PoT, the Human Toxome Knowledge-base, could become a point of reference for toxicological research and regulatory test strategies.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

regulatory toxicology, safety sciences, transcriptomics, metabolomics, alternative methods

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ISO 690BOUHIFD, Mounir, Melvin E. ANDERSEN, Christina BAGHDIKIAN, Kim BOEKELHEIDE, Kevin M. CROFTON, Albert J. FORNACE JR., Andre KLEENSANG, Henghong LI, Carolina LIVI, Alexandra MAERTENS, Patrick D. MCMULLEN, Michael ROSENBERG, Russell THOMAS, Marguerite VANTANGOLI, James D. YAGER, Liang ZHAO, Thomas HARTUNG, 2015. The Human Toxome Project. In: ALTEX : Alternatives to Animal Experimentation. 2015, 32(2), pp. 112-124. ISSN 0946-7785. eISSN 1868-8551. Available under: doi: 10.14573/altex.1502091
BibTex
@article{Bouhifd2015Human-31405,
  year={2015},
  doi={10.14573/altex.1502091},
  title={The Human Toxome Project},
  number={2},
  volume={32},
  issn={0946-7785},
  journal={ALTEX : Alternatives to Animal Experimentation},
  pages={112--124},
  author={Bouhifd, Mounir and Andersen, Melvin E. and Baghdikian, Christina and Boekelheide, Kim and Crofton, Kevin M. and Fornace Jr., Albert J. and Kleensang, Andre and Li, Henghong and Livi, Carolina and Maertens, Alexandra and McMullen, Patrick D. and Rosenberg, Michael and Thomas, Russell and Vantangoli, Marguerite and Yager, James D. and Zhao, Liang and Hartung, Thomas}
}
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