Publikation:

High-Throughput DNA Sequencing Beyond the Four-Letter Code : Epigenetic Modifications Revealed by Single-Molecule Bypass Kinetics

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2499_summerer.pdf
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2010

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http://nbn-resolving.de/urn:nbn:de:bsz:352-136014
DOI (zitierfähiger Link)
https://doi.org/10.1002/cbic.201000569
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Open Access-Veröffentlichung
Open Access Green

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Chemie: Publikationen
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Core Facility der Universität Konstanz

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Published

Erschienen in

ChemBioChem. 2010, 11(18), pp. 2499-2501. eISSN 1439-4227. Available under: doi: 10.1002/cbic.201000569

Zusammenfassung

SM(A)RT analysis: A new approach for the direct high-throughput analysis of both DNA sequence and epigenetic nucleobase modifications is reviewed. The method, which relies on single-molecule, real-time (SMRT) DNA sequencing and overcomes many of the limitations of previous technologies for detecting methylation, might allow the detection of any nucleotide modifications that affect DNA polymerase bypass kinetics.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
540 Chemie

Schlagwörter

DNA methylation, epigenetics, high-throughput sequencing, nucleosides, polymerases

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ISO 690SUMMERER, Daniel, 2010. High-Throughput DNA Sequencing Beyond the Four-Letter Code : Epigenetic Modifications Revealed by Single-Molecule Bypass Kinetics. In: ChemBioChem. 2010, 11(18), pp. 2499-2501. eISSN 1439-4227. Available under: doi: 10.1002/cbic.201000569
BibTex
@article{Summerer2010HighT-13601,
  year={2010},
  doi={10.1002/cbic.201000569},
  title={High-Throughput DNA Sequencing Beyond the Four-Letter Code : Epigenetic Modifications Revealed by Single-Molecule Bypass Kinetics},
  number={18},
  volume={11},
  journal={ChemBioChem},
  pages={2499--2501},
  author={Summerer, Daniel}
}
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