Publikation: "World Health Organization (WHO) and European Food Safety Authority (EFSA) risk evaluations" : Basis of TDIs and tolerable drinking water levels derived by Germany, EFSA, ECHA, and WHO
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2025
Autor:innen
Greim, Helmut
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Journal of Toxicology and Regulatory Policy (JTRP). International Society of Regulatory Toxicology and Pharmacology. 2025, 1(1), S. 1-4. eISSN 2998-4416. Verfügbar unter: doi: 10.69982/j.jtrp.2025.24.0001
Zusammenfassung
Various national and international agencies have evaluated the available information on per- and polyfluoroalkyl substances (PFAS) to determine no observed adverse effect levels (NOAELs), tolerable daily intake (TDIs) and drinking water standards. In Europe, this includes the German drinking water commission,1 the European Food Safety Agency (EFSA),2 European Chemicals Agency (ECHA)3 as well as the World Health Organization (WHO).4 Health-based guidance values e.g. tolerable weekly intake (TWI) appear to largely depend on what information was considered to be relevant and robust. For both, WHO and EFSA, there is the impression that too little consideration was given to the statistical, biological and experimental design robustness of the data sets that were employed.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
ECHA, EFSA, German drinking water commission, PFAS, TDI, WHO
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DIETRICH, Daniel R., Helmut GREIM, 2025. "World Health Organization (WHO) and European Food Safety Authority (EFSA) risk evaluations" : Basis of TDIs and tolerable drinking water levels derived by Germany, EFSA, ECHA, and WHO. In: Journal of Toxicology and Regulatory Policy (JTRP). International Society of Regulatory Toxicology and Pharmacology. 2025, 1(1), S. 1-4. eISSN 2998-4416. Verfügbar unter: doi: 10.69982/j.jtrp.2025.24.0001BibTex
@article{Dietrich2025-01World-72856,
title={"World Health Organization (WHO) and European Food Safety Authority (EFSA) risk evaluations" : Basis of TDIs and tolerable drinking water levels derived by Germany, EFSA, ECHA, and WHO},
year={2025},
doi={10.69982/j.jtrp.2025.24.0001},
number={1},
volume={1},
journal={Journal of Toxicology and Regulatory Policy (JTRP)},
pages={1--4},
author={Dietrich, Daniel R. and Greim, Helmut}
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<dcterms:abstract>Various national and international agencies have evaluated the available information on per- and polyfluoroalkyl substances (PFAS) to determine no observed adverse effect levels (NOAELs), tolerable daily intake (TDIs) and drinking water standards. In Europe, this includes the German drinking water commission,1 the European Food Safety Agency (EFSA),2 European Chemicals Agency (ECHA)3 as well as the World Health Organization (WHO).4 Health-based guidance values e.g. tolerable weekly intake (TWI) appear to largely depend on what information was considered to be relevant and robust. For both, WHO and EFSA, there is the impression that too little consideration was given to the statistical, biological and experimental design robustness of the data sets that were employed.</dcterms:abstract>
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