Publikation:

Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients

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2000

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Freitag, Marcus
Höxtermann, Stefan
Stücker, Markus
Altmeyer, Peter
Kottke, Andrea

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Cytokine. 2000, 12(10), pp. 1570-1574. ISSN 1043-4666. Available under: doi: 10.1006/cyto.2000.0752

Zusammenfassung

We examined leukocyte counts and ex vivo cytokine response of whole blood to lipopolysaccharide (LPS) or lipoteichoic acid (LTA) in patients under low-dose molgramostim therapy. Patients were injected subcutaneously daily for ten days with 1 μg/kg (n=9) or 2 μg/kg (n=14) molgramostim. Leukocytosis was observed in all patients, but only the eosinophil fraction was significantly increased in relation to other leukocyte populations. Ex vivo IFN-γ release was decreased and IL-10 and IL-1ra secretion were increased in response to LPS or LTA. Thus, in non-neutropenic patients, leukocytosis can already be initiated by low doses of molgramostim. The ex vivo cytokine data suggest that these doses prime blood towards a systemic anti-inflammatory response.

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570 Biowissenschaften, Biologie

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blood, cytokines, growth factors, human, inflammation

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ISO 690HARTUNG, Thomas, Sonja von AULOCK, Marcus FREITAG, Stefan HÖXTERMANN, Markus STÜCKER, Klaus HOFFMANN, Peter ALTMEYER, Andrea KOTTKE, Albrecht WENDEL, 2000. Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients. In: Cytokine. 2000, 12(10), pp. 1570-1574. ISSN 1043-4666. Available under: doi: 10.1006/cyto.2000.0752
BibTex
@article{Hartung2000Blood-8305,
  year={2000},
  doi={10.1006/cyto.2000.0752},
  title={Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients},
  number={10},
  volume={12},
  issn={1043-4666},
  journal={Cytokine},
  pages={1570--1574},
  author={Hartung, Thomas and Aulock, Sonja von and Freitag, Marcus and Höxtermann, Stefan and Stücker, Markus and Hoffmann, Klaus and Altmeyer, Peter and Kottke, Andrea and Wendel, Albrecht}
}
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