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Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins

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Membrane_elastic_fluctuations_and_the_insertion_and_tilt_of_beta_barrel_proteins.pdf
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Datum

2006

Autor:innen

Marsh, Derek
Shanmugavadivu, Baladhandapani

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-55532
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https://doi.org/10.1529/biophysj.105.079004
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Attribution-NonCommercial-NoDerivs 2.0 Generic

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Open Access Green

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Published

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Biophysical Journal. 2006, 91(1), pp. 227-232. ISSN 0006-3495. Available under: doi: 10.1529/biophysj.105.079004

Zusammenfassung

Folding of porin-like β-barrel outer membrane proteins can be achieved in the presence of phospholipid vesicles, and takes place concurrently with incorporation into the membrane. The pronounced dependence found for the insertion of the protein OmpA on membrane thickness (Kleinschmidt, J. H., and L. K. Tamm. 2002. J. Mol. Biol. 324:319 330) is analyzed interms of the effects of out-of-plane elastic fluctuations on the area dilation modulus (Evans, E., and W. Rawicz. 1990. Phys. Rev. Lett. 64:2094 2097). For unstrained large unilamellar vesicles, the elastic free energy for membrane insertion is predicted to depend on the fourth power of the membrane thickness. The influence of thermally induced bending fluctuations on the effective tilt of the OmpA β-barrel in disaturated phosphatidylcholine membranes of different thicknesses (Ramakrishnan, M., J.Qu, C. L. Pocanschi, J. H. Kleinschmidt, and D. Marsh. 2005. Biochemistry. 44:3515 3523) is also considered. A contribution to the orientational order parameter that scales as the inverse second power of the membrane thickness is predicted.

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570 Biowissenschaften, Biologie

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ISO 690MARSH, Derek, Baladhandapani SHANMUGAVADIVU, Jörg KLEINSCHMIDT, 2006. Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins. In: Biophysical Journal. 2006, 91(1), pp. 227-232. ISSN 0006-3495. Available under: doi: 10.1529/biophysj.105.079004
BibTex
@article{Marsh2006Membr-7138,
  year={2006},
  doi={10.1529/biophysj.105.079004},
  title={Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins},
  number={1},
  volume={91},
  issn={0006-3495},
  journal={Biophysical Journal},
  pages={227--232},
  author={Marsh, Derek and Shanmugavadivu, Baladhandapani and Kleinschmidt, Jörg}
}
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