Publikation: A third interferon-gamma-induced subunit exchange in the 20S proteasome
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Datum
1996
Autor:innen
Kraft, Regine
Kostka, Susanne
Standera, Sybille
Stohwasser, Ralf
Kloetzel, Peter-Michael
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European Journal of Immunology. 1996, 26(4), pp. 863-869. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.1830260421
Zusammenfassung
The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex (MHC)-encoded and interferon-gamma (IFN-gamma)-inducible subunits LMP2 and LMP7, respectively. LMP2 and LMP7 alter the cleavage site specificity of the 20S proteasome and are required for the efficient generation of T cell epitopes from a number of viral proteins and for optimal MHC class I cell surface expression. We compared the 20S proteasome subunit pattern from IFN-gamma-induced and non-induced mouse fibroblasts on two-dimensional gels and identified a third subunit exchange by microsequencing: the non-MHC-encoded subunit MECL-1 is induced by IFN-gamma and replaces a sofar barely characterized beta subunit designated 'MC14'. In analogy to LMP2 and LMP7, MECL-1 may be functional in MHC class I-restricted antigen presentation.
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570 Biowissenschaften, Biologie
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GRÖTTRUP, Marcus, Regine KRAFT, Susanne KOSTKA, Sybille STANDERA, Ralf STOHWASSER, Peter-Michael KLOETZEL, 1996. A third interferon-gamma-induced subunit exchange in the 20S proteasome. In: European Journal of Immunology. 1996, 26(4), pp. 863-869. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.1830260421BibTex
@article{Grottrup1996-04third-22319,
year={1996},
doi={10.1002/eji.1830260421},
title={A third interferon-gamma-induced subunit exchange in the 20S proteasome},
number={4},
volume={26},
issn={0014-2980},
journal={European Journal of Immunology},
pages={863--869},
author={Gröttrup, Marcus and Kraft, Regine and Kostka, Susanne and Standera, Sybille and Stohwasser, Ralf and Kloetzel, Peter-Michael}
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<dcterms:abstract xml:lang="eng">The 20S proteasome is a protease complex of functional importance for antigen processing. Two of the 14 proteasome subunits, delta and MB1, can be replaced by the major histocompatibility complex (MHC)-encoded and interferon-gamma (IFN-gamma)-inducible subunits LMP2 and LMP7, respectively. LMP2 and LMP7 alter the cleavage site specificity of the 20S proteasome and are required for the efficient generation of T cell epitopes from a number of viral proteins and for optimal MHC class I cell surface expression. We compared the 20S proteasome subunit pattern from IFN-gamma-induced and non-induced mouse fibroblasts on two-dimensional gels and identified a third subunit exchange by microsequencing: the non-MHC-encoded subunit MECL-1 is induced by IFN-gamma and replaces a sofar barely characterized beta subunit designated 'MC14'. In analogy to LMP2 and LMP7, MECL-1 may be functional in MHC class I-restricted antigen presentation.</dcterms:abstract>
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