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Goose RIG-I functions in innate immunity against Newcastle disease virus infections

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2013

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Sun, Yingjie
Ding, Na
Yu, Shengqing
Meng, Chunhun
Chen, Hongjun
Qiu, Xusheng
Zhang, Shilei
Yu, Yang
Ding, Chan
et al.

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https://doi.org/10.1016/j.molimm.2012.08.022
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Molecular Immunology. Elsevier. 2013, 53(4), pp. 321-327. ISSN 0161-5890. eISSN 1872-9142. Available under: doi: 10.1016/j.molimm.2012.08.022

Zusammenfassung

Mammalian retinoic acid-inducible gene I (RIG-I) is a chief antiviral gene sensing viral RNA molecules including Newcastle disease virus (NDV). In this study, goose RIG-I gene (gRIG-I) was identified. The 2805 bp-long gene encodes a gRIG-I protein that exhibits 93.8% amino acid identity to duck RIG-I. DF-1 chicken fibroblast cells transfected with full-length of gRIG-I or CARD domain of gRIG-I plasmids respond significantly to the agonist of 21-mer 5'ppp RNA, evident through enhancement of IFN-β promoter activity. Goose RIG-I transfected 293T/17 cells were then tested for the response to NDV infection, resulting in up-regulated activity of IFN-β promoter, and mRNA levels of IRF-3 and IFIT1, but decreased virus titer. Similar results were obtained in transfected DF-1 chicken fibroblast cells and goose embryo fibroblast cells in response to NDV infections Animal experiments further support a role of gRIG-I in goose innate immunity against NDV infections by showing increased gRIG-I mRNA levels and decreased virus titer in geese lung and air sac post-infection.

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570 Biowissenschaften, Biologie

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ISO 690SUN, Yingjie, Na DING, Serena DING, Shengqing YU, Chunhun MENG, Hongjun CHEN, Xusheng QIU, Shilei ZHANG, Yang YU, Chan DING, 2013. Goose RIG-I functions in innate immunity against Newcastle disease virus infections. In: Molecular Immunology. Elsevier. 2013, 53(4), pp. 321-327. ISSN 0161-5890. eISSN 1872-9142. Available under: doi: 10.1016/j.molimm.2012.08.022
BibTex
@article{Sun2013-04Goose-54682,
  year={2013},
  doi={10.1016/j.molimm.2012.08.022},
  title={Goose RIG-I functions in innate immunity against Newcastle disease virus infections},
  number={4},
  volume={53},
  issn={0161-5890},
  journal={Molecular Immunology},
  pages={321--327},
  author={Sun, Yingjie and Ding, Na and Ding, Serena and Yu, Shengqing and Meng, Chunhun and Chen, Hongjun and Qiu, Xusheng and Zhang, Shilei and Yu, Yang and Ding, Chan}
}
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