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Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity

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2020

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Huang, Zixia
Whelan, Conor V.
Teeling, Emma C.

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Aging. Impact Journals. 2020, 12(16), pp. 15962-15977. eISSN 1945-4589. Available under: doi: 10.18632/aging.103725

Zusammenfassung

Bats are the longest-lived mammals given their body size with majority of species exhibiting exceptional longevity. However, there are some short-lived species that do not exhibit extended lifespans. Here we conducted a comparative genomic and transcriptomic study on long-lived Myotis myotis (maximum lifespan = 37.1 years) and short-lived Molossus molossus (maximum lifespan = 5.6 years) to ascertain the genetic difference underlying their divergent longevities. Genome-wide selection tests on 12,467 single-copy genes between M. myotis and M. molossus revealed only three genes (CCDC175, FATE1 and MLKL) that exhibited significant positive selection. Although 97.96% of 12,467 genes underwent purifying selection, we observed a significant heterogeneity in their expression patterns. Using a linear mixed model, we obtained expression of 2,086 genes that may truly represent the genetic difference between M. myotis and M. molossus. Expression analysis indicated that long-lived M. myotis exhibited a transcriptomic profile of enhanced DNA repair and autophagy pathways, compared to M. molossus. Further investigation of the longevity-associated genes suggested that long-lived M. myotis have naturally evolved a diminished anti-longevity transcriptomic profile. Together with observations from other long-lived species, our results suggest that heightened DNA repair and autophagy activity may represent a universal mechanism to achieve longevity in long-lived mammals.

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570 Biowissenschaften, Biologie

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ISO 690HUANG, Zixia, Conor V. WHELAN, Dina K. N. DECHMANN, Emma C. TEELING, 2020. Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity. In: Aging. Impact Journals. 2020, 12(16), pp. 15962-15977. eISSN 1945-4589. Available under: doi: 10.18632/aging.103725
BibTex
@article{Huang2020-09-05Genet-51160,
  year={2020},
  doi={10.18632/aging.103725},
  title={Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity},
  number={16},
  volume={12},
  journal={Aging},
  pages={15962--15977},
  author={Huang, Zixia and Whelan, Conor V. and Dechmann, Dina K. N. and Teeling, Emma C.}
}
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