Publikation:

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

Lade...
Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2003

Autor:innen

Brès, Vanessa
Kiernan, Rosemary E
Linares, Laetitia K.
Chable-Bessia, Christine
Plechakova, Olga
Tréand, Céline
Emiliani, Stephane
Peloponese, Jean-Marie
Benkirane, Monsef
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Nature cell biology. 2003, 5(8), pp. 754-761. ISSN 1465-7392. eISSN 1476-4679. Available under: doi: 10.1038/ncb1023

Zusammenfassung

The human immunodeficiency virus type 1 (HIV-1) encodes a potent transactivator, Tat, which functions through binding to a short leader RNA, called transactivation responsive element (TAR). Recent studies suggest that Tat activates the HIV-1 long terminal repeat (LTR), mainly by adapting co-activator complexes, such as p300, PCAF and the positive transcription elongation factor P-TEFb, to the promoter. Here, we show that the proto-oncoprotein Hdm2 interacts with Tat and mediates its ubiquitination in vitro and in vivo. In addition, Hdm2 is a positive regulator of Tat-mediated transactivation, indicating that the transcriptional properties of Tat are stimulated by ubiquitination. Fusion of ubiquitin to Tat bypasses the requirement of Hdm2 for efficient transactivation, supporting the notion that ubiquitin has a non-proteolytic function in Tat-mediated transactivation.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690BRÈS, Vanessa, Rosemary E KIERNAN, Laetitia K. LINARES, Christine CHABLE-BESSIA, Olga PLECHAKOVA, Céline TRÉAND, Stephane EMILIANI, Jean-Marie PELOPONESE, Martin SCHEFFNER, Monsef BENKIRANE, 2003. A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. In: Nature cell biology. 2003, 5(8), pp. 754-761. ISSN 1465-7392. eISSN 1476-4679. Available under: doi: 10.1038/ncb1023
BibTex
@article{Bres2003-08nonpr-42225,
  year={2003},
  doi={10.1038/ncb1023},
  title={A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter},
  number={8},
  volume={5},
  issn={1465-7392},
  journal={Nature cell biology},
  pages={754--761},
  author={Brès, Vanessa and Kiernan, Rosemary E and Linares, Laetitia K. and Chable-Bessia, Christine and Plechakova, Olga and Tréand, Céline and Emiliani, Stephane and Peloponese, Jean-Marie and Scheffner, Martin and Benkirane, Monsef}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/42225">
    <dc:creator>Scheffner, Martin</dc:creator>
    <dc:creator>Benkirane, Monsef</dc:creator>
    <dcterms:abstract xml:lang="eng">The human immunodeficiency virus type 1 (HIV-1) encodes a potent transactivator, Tat, which functions through binding to a short leader RNA, called transactivation responsive element (TAR). Recent studies suggest that Tat activates the HIV-1 long terminal repeat (LTR), mainly by adapting co-activator complexes, such as p300, PCAF and the positive transcription elongation factor P-TEFb, to the promoter. Here, we show that the proto-oncoprotein Hdm2 interacts with Tat and mediates its ubiquitination in vitro and in vivo. In addition, Hdm2 is a positive regulator of Tat-mediated transactivation, indicating that the transcriptional properties of Tat are stimulated by ubiquitination. Fusion of ubiquitin to Tat bypasses the requirement of Hdm2 for efficient transactivation, supporting the notion that ubiquitin has a non-proteolytic function in Tat-mediated transactivation.</dcterms:abstract>
    <dc:contributor>Peloponese, Jean-Marie</dc:contributor>
    <dc:contributor>Emiliani, Stephane</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-02T08:02:23Z</dcterms:available>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-02T08:02:23Z</dc:date>
    <dc:creator>Peloponese, Jean-Marie</dc:creator>
    <dc:contributor>Brès, Vanessa</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42225"/>
    <dc:contributor>Chable-Bessia, Christine</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Chable-Bessia, Christine</dc:creator>
    <dcterms:title>A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter</dcterms:title>
    <dc:contributor>Kiernan, Rosemary E</dc:contributor>
    <dc:creator>Kiernan, Rosemary E</dc:creator>
    <dc:contributor>Scheffner, Martin</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Brès, Vanessa</dc:creator>
    <dc:contributor>Tréand, Céline</dc:contributor>
    <dc:creator>Emiliani, Stephane</dc:creator>
    <dc:creator>Tréand, Céline</dc:creator>
    <dc:contributor>Linares, Laetitia K.</dc:contributor>
    <dc:creator>Linares, Laetitia K.</dc:creator>
    <dcterms:issued>2003-08</dcterms:issued>
    <dc:creator>Plechakova, Olga</dc:creator>
    <dc:contributor>Plechakova, Olga</dc:contributor>
    <dc:contributor>Benkirane, Monsef</dc:contributor>
    <dc:language>eng</dc:language>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen