Publikation: On the role of the immunoproteasome in transplant rejection
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2019
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Immunogenetics. 2019, 71(3), pp. 263-271. ISSN 0093-7711. eISSN 1432-1211. Available under: doi: 10.1007/s00251-018-1084-0
Zusammenfassung
The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated cancer formation, and transplantation. Immunoproteasome inhibition prevents activation and proliferation of lymphocytes, lowers MHC class I cell surface expression, reduces the expression of cytokines of activated immune cells, and curtails T helper 1 and 17 cell differentiation. This might explain the in vivo efficacy of immunoproteasome inhibition in different pre-clinical disease models for autoimmunity, cancer, and transplantation. In this review, we summarize the effect of immunoproteasome inhibition in different animal models for transplantation.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Proteasome, Immunoproteasome, Antigen processing, Antigen presentation, Transplantation
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BASLER, Michael, Jun LI, Marcus GRÖTTRUP, 2019. On the role of the immunoproteasome in transplant rejection. In: Immunogenetics. 2019, 71(3), pp. 263-271. ISSN 0093-7711. eISSN 1432-1211. Available under: doi: 10.1007/s00251-018-1084-0BibTex
@article{Basler2019-03immun-43313,
year={2019},
doi={10.1007/s00251-018-1084-0},
title={On the role of the immunoproteasome in transplant rejection},
number={3},
volume={71},
issn={0093-7711},
journal={Immunogenetics},
pages={263--271},
author={Basler, Michael and Li, Jun and Gröttrup, Marcus}
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