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Chemical warfare agents : Classes and targets

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2018

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https://doi.org/10.1016/j.toxlet.2017.11.040
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Toxicology Letters. Elsevier. 2018, 293, pp. 253-263. ISSN 0378-4274. eISSN 1879-3169. Available under: doi: 10.1016/j.toxlet.2017.11.040

Zusammenfassung

Synthetic toxic chemicals (toxicants) and biological poisons (toxins) have been developed as chemical warfare agents in the last century. At the time of their initial consideration as chemical weapon, only restricted knowledge existed about their mechanisms of action. There exist two different types of acute toxic action: nonspecific cytotoxic mechanisms with multiple chemo-biological interactions versus specific mechanisms that tend to have just a single or a few target biomolecules. TRPV1- and TRPA-receptors are often involved as chemosensors that induce neurogenic inflammation. The present work briefly surveys classes and toxicologically relevant features of chemical warfare agents and describes mechanisms of toxic action.

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Chemical weapon, Chemical warfare agent, TRP, Toxic, Neurogenic inflammation

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ISO 690SCHWENK, Michael, 2018. Chemical warfare agents : Classes and targets. In: Toxicology Letters. Elsevier. 2018, 293, pp. 253-263. ISSN 0378-4274. eISSN 1879-3169. Available under: doi: 10.1016/j.toxlet.2017.11.040
BibTex
@article{Schwenk2018-09-01Chemi-55157,
  year={2018},
  doi={10.1016/j.toxlet.2017.11.040},
  title={Chemical warfare agents : Classes and targets},
  volume={293},
  issn={0378-4274},
  journal={Toxicology Letters},
  pages={253--263},
  author={Schwenk, Michael}
}
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