Publikation: Crosstalk of small GTPases at the Golgi apparatus
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2012
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Small GTPases. 2012, 3(2), pp. 80-90. ISSN 2154-1248. eISSN 2154-1256. Available under: doi: 10.4161/sgtp.19842
Zusammenfassung
Small GTPases regulate a wide range of homeostatic processes such as cytoskeletal dynamics, organelle homeostasis, cell migration and vesicle trafficking, as well as in pathologic conditions such as carcinogenesis and metastatic spreading. Therefore, it is important to understand the regulation of small GTPase signaling, but this is complicated by the fact that crosstalk exists between different GTPase families and that we have to understand how they signal in time and space. The Golgi apparatus represents a hub for several signaling molecules and its importance in this field is constantly increasing. In this review we will discuss small GTPases signaling at the Golgi apparatus. Then, we will highlight recent work that contributed to a better understanding of crosstalk between different small GTPase families, with a special emphasis on their crosstalk at the Golgi apparatus. Finally, we will give a brief overview of available methods and tools to investigate spatio-temporal small GTPase crosstalk.
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570 Biowissenschaften, Biologie
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BASCHIERI, Francesco, Hesso FARHAN, 2012. Crosstalk of small GTPases at the Golgi apparatus. In: Small GTPases. 2012, 3(2), pp. 80-90. ISSN 2154-1248. eISSN 2154-1256. Available under: doi: 10.4161/sgtp.19842BibTex
@article{Baschieri2012-04Cross-21325,
year={2012},
doi={10.4161/sgtp.19842},
title={Crosstalk of small GTPases at the Golgi apparatus},
number={2},
volume={3},
issn={2154-1248},
journal={Small GTPases},
pages={80--90},
author={Baschieri, Francesco and Farhan, Hesso}
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<dcterms:abstract xml:lang="eng">Small GTPases regulate a wide range of homeostatic processes such as cytoskeletal dynamics, organelle homeostasis, cell migration and vesicle trafficking, as well as in pathologic conditions such as carcinogenesis and metastatic spreading. Therefore, it is important to understand the regulation of small GTPase signaling, but this is complicated by the fact that crosstalk exists between different GTPase families and that we have to understand how they signal in time and space. The Golgi apparatus represents a hub for several signaling molecules and its importance in this field is constantly increasing. In this review we will discuss small GTPases signaling at the Golgi apparatus. Then, we will highlight recent work that contributed to a better understanding of crosstalk between different small GTPase families, with a special emphasis on their crosstalk at the Golgi apparatus. Finally, we will give a brief overview of available methods and tools to investigate spatio-temporal small GTPase crosstalk.</dcterms:abstract>
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