Case-by-case : Emotional stimulus significance and the modulation of the EPN and LPP

Abstract

Stimuli encountered in the environment are continuously evaluated according to their affective stimulus significance. Numerous event-related potential studies have shown that the early posterior negativity (EPN) and the late positive potential (LPP) are larger for pictures high in emotional arousal compared to low arousing images. Here, we used a case-by-case approach to determine the emotional modulation of the EPN and LPP at the level of the individual case. We probed the effect in three studies regarding behavior systems of predator fear, disease avoidance, and sexual reproduction. In each study, high and low arousing pictures from the respective behavior system were presented and event-related brain potentials measured. At the group level, previous findings regarding an enhanced EPN and LPP for high compared to low arousing stimuli were replicated. Novel findings were observed when analyzing each case individually. The majority of participants showed significantly larger EPN and LPP amplitudes to pictures showing threatening compared to harmless animals (15 and 16 out of 16 tests, respectively), images of disease and mutilation compared to neutral people (15 and 17 out of 18 tests, respectively), and high-arousing erotic compared to romantic pictures (17 and 17 out of 17 tests, respectively). Further analyses exploring the tradeoff between specificity and sensitivity suggest reliance on picture categories of sexual reproduction and disease avoidance. Overall, the present findings demonstrate that the case-by-case approach can be useful for revealing a general principle of emotional stimulus processing common-to-all. Implications for the reproducibility of the findings and biomarker development are discussed.