Increased Levels of Antigen-Bound beta-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer's Disease Patients

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2013
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Schnack, Cathrin
Tumani, Hayrettin
Otto, Markus
Arnim, Christine A. F. von
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Recent studies have suggested a protective role of physiological β-amyloid autoantibodies (Aβ-autoantibodies) in Alzheimer's disease (AD). However, the determination of both free and dissociated Aβ-autoantibodies in serum hitherto has yielded inconsistent results regarding their function and possible biomarker value. Here we report the application of a new sandwich enzyme-linked immunosorbent assay (ELISA) for the determination of antigen-bound Aβ-autoantibodies (intact Aβ-IgG immune complexes) in serum and cerebrospinal fluid (CSF) of a total number of 112 AD patients and age- and gender-matched control subjects. Both serum and CSF levels of Aβ-IgG immune complexes were found to be significantly higher in AD patients compared to control subjects. Moreover, the levels of Aβ-IgG complexes were negatively correlated with the cognitive status across the groups, increasing with declining cognitive test performance of the subjects. Our results suggest a contribution of IgG-type autoantibodies to Aβ clearance in vivo and an increased immune response in AD, which may be associated with deficient Aβ-IgG removal. These findings may contribute to elucidating the role of Aβ-autoantibodies in AD pathophysiology and their potential application in AD diagnosis.

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ISO 690MAFTEI, Madalina, Franka THURM, Cathrin SCHNACK, Hayrettin TUMANI, Markus OTTO, Thomas ELBERT, Iris-Tatjana KOLASSA, Michael PRZYBYLSKI, Marilena MANEA, Christine A. F. von ARNIM, 2013. Increased Levels of Antigen-Bound beta-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer's Disease Patients. In: PLoS ONE. 2013, 8(7), e68996. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0068996
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@article{Maftei2013Incre-24148,
  year={2013},
  doi={10.1371/journal.pone.0068996},
  title={Increased Levels of Antigen-Bound beta-Amyloid Autoantibodies in Serum and Cerebrospinal Fluid of Alzheimer's Disease Patients},
  number={7},
  volume={8},
  journal={PLoS ONE},
  author={Maftei, Madalina and Thurm, Franka and Schnack, Cathrin and Tumani, Hayrettin and Otto, Markus and Elbert, Thomas and Kolassa, Iris-Tatjana and Przybylski, Michael and Manea, Marilena and Arnim, Christine A. F. von},
  note={Article Number: e68996}
}
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