Cotranslational sorting and processing of newly synthesized proteins in eukaryotes

Kurzanzeige
dc.contributor.authorGamerdinger, Martin
dc.contributor.authorDeuerling, Elke
dc.date.accessioned2024-03-08T09:31:54Z
dc.date.available2024-03-08T09:31:54Z
dc.date.issued2024
dc.description.abstractRibosomes interact with a variety of different protein biogenesis factors that guide newly synthesized proteins to their native 3D shapes and cellular localization. Depending on the type of translated substrate, a distinct set of cotranslational factors must interact with the ribosome in a timely and coordinated manner to ensure proper protein biogenesis. While cytonuclear proteins require cotranslational maturation and folding factors, secretory proteins must be maintained in an unfolded state and processed cotranslationally by transport and membrane translocation factors. Here we explore the specific cotranslational processing steps for cytonuclear, secretory, and membrane proteins in eukaryotes and then discuss how the nascent polypeptide-associated complex (NAC) cotranslationally sorts these proteins into the correct protein biogenesis pathway.
dc.description.versionpublisheddeu
dc.identifier.doi10.1016/j.tibs.2023.10.003
dc.identifier.ppn1882953398
dc.identifier.urihttps://kops.uni-konstanz.de/handle/123456789/69566
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc570
dc.titleCotranslational sorting and processing of newly synthesized proteins in eukaryoteseng
dc.typeJOURNAL_ARTICLE
dspace.entity.typePublication
kops.citation.bibtex
@article{Gamerdinger2024Cotra-69566,
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  doi={10.1016/j.tibs.2023.10.003},
  title={Cotranslational sorting and processing of newly synthesized proteins in eukaryotes},
  number={2},
  volume={49},
  issn={0968-0004},
  journal={Trends in Biochemical Sciences},
  pages={105--118},
  author={Gamerdinger, Martin and Deuerling, Elke}
}
kops.citation.iso690GAMERDINGER, Martin, Elke DEUERLING, 2024. Cotranslational sorting and processing of newly synthesized proteins in eukaryotes. In: Trends in Biochemical Sciences. Elsevier. 2024, 49(2), pp. 105-118. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2023.10.003deu
kops.citation.iso690GAMERDINGER, Martin, Elke DEUERLING, 2024. Cotranslational sorting and processing of newly synthesized proteins in eukaryotes. In: Trends in Biochemical Sciences. Elsevier. 2024, 49(2), pp. 105-118. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2023.10.003eng
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kops.sourcefield.plainTrends in Biochemical Sciences. Elsevier. 2024, 49(2), pp. 105-118. ISSN 0968-0004. eISSN 1362-4326. Available under: doi: 10.1016/j.tibs.2023.10.003eng
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