Publikation:

Free Cortisol Levels after Awakening : A Reliable Biological Marker for the Assessment of Adrenocortical Activity

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Datum

1997

Autor:innen

Wolf, Oliver T.
Hellhammer, Dirk H.
Buske-Kirschbaum, Angelika
von Auer, Kristin
Jobst, Silke
Kaspers, Frank
Kirschbaum, Clemens

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-pma17l31c6061
DOI (zitierfähiger Link)
https://doi.org/10.1016/s0024-3205(97)01008-4
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Internationale Patentnummer

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oops

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Open Access-Veröffentlichung
Open Access Green

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Psychologie: Publikationen
Core Facility der Universität Konstanz

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Titel in einer weiteren Sprache

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Published

Erschienen in

Life Sciences. Elsevier BV. 1997, 61(26), S. 2539-2549. ISSN 0024-3205. Verfügbar unter: doi: 10.1016/s0024-3205(97)01008-4

Zusammenfassung

In three independent studies, free cortisol levels after morning awakening were repeatedly measured in children, adults and elderly subjects (total n= 152). Cortisol was assessed by sampling saliva at 10 or 15 minute intervals for 30–60 minutes, beginning at the time of awakening for two days (Study 1 and 2) or one (Study 3) day, respectively. In all three studies, free cortisol levels increased by 50–75% within the first 30 minutes after awakening in both sexes on all days. Premenopausal women consistently showed a stronger increase with a delayed peak after awakening compared to men on all days. In Study 2, there was a tendency for lower early morning free cortisol levels for women taking oral contraceptives (p=.10). Stability of the area under the curve (AUC) of the early morning free cortisol levels over the three (Study 1 and 2) or two (Study 3) days ranged between r=.39 and r=.67 (p<.001). Neither age, weight, nor smoking showed an effect on baseline or peak cortisol levels. Sleep duration, time of awakening and alcohol consumption also appeared to be unrelated to early morning free cortisol levels. From these data we conclude that in contrast to single assessments at fixed times, early morning cortisol levels can be a reliable biological marker for the individual's adrenocortical activity when measured repeatedly with strict reference to the time of awakening.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

saliva, cortisol, awakening, oral contraceptives, sex differences, age

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ISO 690PRUESSNER, Jens C., Oliver T. WOLF, Dirk H. HELLHAMMER, Angelika BUSKE-KIRSCHBAUM, Kristin VON AUER, Silke JOBST, Frank KASPERS, Clemens KIRSCHBAUM, 1997. Free Cortisol Levels after Awakening : A Reliable Biological Marker for the Assessment of Adrenocortical Activity. In: Life Sciences. Elsevier BV. 1997, 61(26), S. 2539-2549. ISSN 0024-3205. Verfügbar unter: doi: 10.1016/s0024-3205(97)01008-4
BibTex
@article{Pruessner1997-11Corti-70050,
  year={1997},
  doi={10.1016/s0024-3205(97)01008-4},
  title={Free Cortisol Levels after Awakening : A Reliable Biological Marker for the Assessment of Adrenocortical Activity},
  number={26},
  volume={61},
  issn={0024-3205},
  journal={Life Sciences},
  pages={2539--2549},
  author={Pruessner, Jens C. and Wolf, Oliver T. and Hellhammer, Dirk H. and Buske-Kirschbaum, Angelika and von Auer, Kristin and Jobst, Silke and Kaspers, Frank and Kirschbaum, Clemens}
}
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