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Programmable Sensors of 5-Hydroxymethylcytosine

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2015

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Kubik, Grzegorz
Batke, Sabrina
Summerer, Daniel

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https://doi.org/10.1021/ja506022t
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Journal of the American Chemical Society : JACS. 2015, 137(1), pp. 2-5. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja506022t

Zusammenfassung

5-Hydroxymethylcytosine (hmC), the sixth base of the mammalian genome, is increasingly recognized as an epigenetic mark with important biological functions. We report engineered, programmable transcription-activator-like effectors (TALEs) as the first DNA-binding receptor molecules that provide direct, individual selectivities for cytosine (C), 5-methylcytosine (mC), and hmC at user-defined DNA sequences. Given the wide applicability of TALEs for programmable targeting of DNA sequences in vitro and in vivo, this provides broad perspectives for epigenetic research.

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540 Chemie

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ISO 690KUBIK, Grzegorz, Sabrina BATKE, Daniel SUMMERER, 2015. Programmable Sensors of 5-Hydroxymethylcytosine. In: Journal of the American Chemical Society : JACS. 2015, 137(1), pp. 2-5. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja506022t
BibTex
@article{Kubik2015Progr-30896,
  year={2015},
  doi={10.1021/ja506022t},
  title={Programmable Sensors of 5-Hydroxymethylcytosine},
  number={1},
  volume={137},
  issn={0002-7863},
  journal={Journal of the American Chemical Society : JACS},
  pages={2--5},
  author={Kubik, Grzegorz and Batke, Sabrina and Summerer, Daniel}
}
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