Publikation: Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases
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2017
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Journal of Pharmacokinetics and Pharmacodynamics. 2017, 44(1), pp. 27-42. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9502-0
Zusammenfassung
We present competitive and uncompetitive drug-drug interaction (DDI) with target mediated drug disposition (TMDD) equations and investigate their pharmacokinetic DDI properties. For application of TMDD models, quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are necessary to reduce the number of parameters. To realize those approximations of DDI TMDD models, we derive an ordinary differential equation (ODE) representation formulated in free concentration and free receptor variables. This ODE formulation can be straightforward implemented in typical PKPD software without solving any non-linear equation system arising from the QE or QSS approximation of the rapid binding assumptions. This manuscript is the second in a series to introduce and investigate DDI TMDD models and to apply the QE or QSS approximation.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
510 Mathematik
Schlagwörter
Drug–drug interaction, Target-mediated drug disposition, Competitive, Uncompetitive
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KOCH, Gilbert, William J. JUSKO, Johannes SCHROPP, 2017. Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases. In: Journal of Pharmacokinetics and Pharmacodynamics. 2017, 44(1), pp. 27-42. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9502-0BibTex
@article{Koch2017-02Targe-38417,
year={2017},
doi={10.1007/s10928-016-9502-0},
title={Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases},
number={1},
volume={44},
issn={1567-567X},
journal={Journal of Pharmacokinetics and Pharmacodynamics},
pages={27--42},
author={Koch, Gilbert and Jusko, William J. and Schropp, Johannes}
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<dcterms:abstract xml:lang="eng">We present competitive and uncompetitive drug-drug interaction (DDI) with target mediated drug disposition (TMDD) equations and investigate their pharmacokinetic DDI properties. For application of TMDD models, quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are necessary to reduce the number of parameters. To realize those approximations of DDI TMDD models, we derive an ordinary differential equation (ODE) representation formulated in free concentration and free receptor variables. This ODE formulation can be straightforward implemented in typical PKPD software without solving any non-linear equation system arising from the QE or QSS approximation of the rapid binding assumptions. This manuscript is the second in a series to introduce and investigate DDI TMDD models and to apply the QE or QSS approximation.</dcterms:abstract>
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