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Organoid intelligence for developmental neurotoxicity testing

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Datum

2024

Autor:innen

Alam El Din, Dowlette-Mary
Shin, Jeongwon
Lysinger, Alexandra
Roos, Matthew J.
Johnson, Erik C.
Shafer, Timothy J.
Smirnova, Lena

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Published

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Frontiers in Cellular Neuroscience. Frontiers. 2024, 18, 1480845. eISSN 1662-5102. Verfügbar unter: doi: 10.3389/fncel.2024.1480845

Zusammenfassung

The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence (OI); leveraging brain organoids to study neuroplasticity in vitro, into the DNT testing paradigm. OI brings a new approach to measure the impacts of xenobiotics on plasticity mechanisms – a critical biological process that is not adequately covered in current DNT in vitro assays. Finally, the integration of artificial intelligence (AI) techniques will further facilitate the analysis of complex brain organoid data to study these plasticity mechanisms.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

organoid, organoid intelligence, developmental neurotoxicity, artificial intelligence, machine learning, synaptic plasiticity

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ISO 690ALAM EL DIN, Dowlette-Mary, Jeongwon SHIN, Alexandra LYSINGER, Matthew J. ROOS, Erik C. JOHNSON, Timothy J. SHAFER, Thomas HARTUNG, Lena SMIRNOVA, 2024. Organoid intelligence for developmental neurotoxicity testing. In: Frontiers in Cellular Neuroscience. Frontiers. 2024, 18, 1480845. eISSN 1662-5102. Verfügbar unter: doi: 10.3389/fncel.2024.1480845
BibTex
@article{AlamElDin2024-10-08Organ-71603,
  year={2024},
  doi={10.3389/fncel.2024.1480845},
  title={Organoid intelligence for developmental neurotoxicity testing},
  volume={18},
  journal={Frontiers in Cellular Neuroscience},
  author={Alam El Din, Dowlette-Mary and Shin, Jeongwon and Lysinger, Alexandra and Roos, Matthew J. and Johnson, Erik C. and Shafer, Timothy J. and Hartung, Thomas and Smirnova, Lena},
  note={Article Number: 1480845}
}
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