Annihilation of action potentials induces electrical coupling between neurons

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2023
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eLife. eLife Sciences Publications. eISSN 2050-084X. Available under: doi: 10.7554/elife.88335.1
Zusammenfassung

Neurons generate and propagate electrical pulses called action potentials which annihilate on arrival at the axon terminal. We measure the extracellular electric field generated by propagating and annihilating action potentials and find that on annihilation, action potentials expel a local discharge. The discharge at the axon terminal generates an inhomogeneous electric field that immediately influences target neurons and thus provokes ephaptic coupling. Our measurements are quantitatively verified by a powerful analytical model which reveals excitation and inhibition in target neurons, depending on position and morphology of the source-target arrangement. Our model is in full agreement with experimental findings on ephaptic coupling at the well-studied Basket cell - Purkinje cell synapse. It is able to predict ephaptic coupling for any other synaptic geometry as illustrated by a few examples.

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570 Biowissenschaften, Biologie
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ISO 690SCHLÖTTER, Moritz, Georg MARET, Christoph KLEINEIDAM, 2023. Annihilation of action potentials induces electrical coupling between neurons. In: eLife. eLife Sciences Publications. eISSN 2050-084X. Available under: doi: 10.7554/elife.88335.1
BibTex
@article{Schlotter2023-08-16Annih-67692,
  year={2023},
  doi={10.7554/elife.88335.1},
  title={Annihilation of action potentials induces electrical coupling between neurons},
  journal={eLife},
  author={Schlötter, Moritz and Maret, Georg and Kleineidam, Christoph}
}
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