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Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete

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2021

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Awakawa, Takayoshi
Abe, Ikuro

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Journal of Industrial Microbiology and Biotechnology. Oxford University Press. 2021, 48(3-4), kuab001. ISSN 1367-5435. eISSN 1476-5535. Available under: doi: 10.1093/jimb/kuab001

Zusammenfassung

Sulfonamides and sulfamates are a group of organosulfur compounds that contain the signature sulfamoyl structural motif. These compounds were initially only known as synthetic antibacterial drugs but were later also discovered as natural products. Eight highly potent examples have been isolated from actinomycetes to date, illustrating the large biosynthetic repertoire of this bacterial genus. For the biosynthesis of these compounds, several distinct and unique biosynthetic machineries have been discovered, capable to generate the unique S-N bond. For the creation of novel, second generation natural products by biosynthetic engineering efforts, a detailed understanding of the underlying enzyme machinery toward potent structural motifs is crucial. In this review, we aim to summarize the current state of knowledge on sulfonamide and sulfamate biosynthesis. A detailed discussion for the secondary sulfamate ascamycin, the tertiary sulfonamide sulfadixiamycin A, and the secondary sulfonamide SB-203208 is provided and their bioactivities and mode of actions are discussed.

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540 Chemie

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ISO 690AWAKAWA, Takayoshi, Lena BARRA, Ikuro ABE, 2021. Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete. In: Journal of Industrial Microbiology and Biotechnology. Oxford University Press. 2021, 48(3-4), kuab001. ISSN 1367-5435. eISSN 1476-5535. Available under: doi: 10.1093/jimb/kuab001
BibTex
@article{Awakawa2021-06-04Biosy-57550,
  year={2021},
  doi={10.1093/jimb/kuab001},
  title={Biosynthesis of sulfonamide and sulfamate antibiotics in actinomycete},
  number={3-4},
  volume={48},
  issn={1367-5435},
  journal={Journal of Industrial Microbiology and Biotechnology},
  author={Awakawa, Takayoshi and Barra, Lena and Abe, Ikuro},
  note={Article Number: kuab001}
}
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