Publikation:

Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study

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Moreno_2-mrn2222q9u976.pdf
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2019

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-mrn2222q9u976
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.mad.2018.06.006
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Biologie: Publikationen
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Mechanisms of Ageing and Development. 2019, 177, pp. 128-134. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2018.06.006

Zusammenfassung

Ageing is a multifactorial process that affects most, if not all, of the body’s tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that ‘biological age’ of a person may be different from ‘chronological age’. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Therefore, establishment of markers of biological ageing is important for preventing age-associated diseases and extending health span. MARK-AGE, a large-scale European study, aimed at identifying a set of biomarkers which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. But beyond the identification of useful biomarkers, MARK-AGE provided new insights in age-associated specific cellular processes, such as DNA methylation, oxidative stress and the regulation of zinc homeostasis.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Human ageing, Biomarkers, Chronological age, Biological age, Health span, Observational study, Europe, Nutrition, Peripheral blood mononuclear cells, DNA damage, Epigenetics, Oxidative stress, Zinc homeostasis, DNA methyltransferases, en-eleven translocation family of 5-mC hydroxylases, Vaccination

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ISO 690MORENO-VILLANUEVA, Maria, Alexander BÜRKLE, 2019. Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study. In: Mechanisms of Ageing and Development. 2019, 177, pp. 128-134. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2018.06.006
BibTex
@article{MorenoVillanueva2019Epige-45053,
  year={2019},
  doi={10.1016/j.mad.2018.06.006},
  title={Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study},
  volume={177},
  issn={0047-6374},
  journal={Mechanisms of Ageing and Development},
  pages={128--134},
  author={Moreno-Villanueva, Maria and Bürkle, Alexander}
}
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