Publikation:

Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study

Vorschaubild

Dateien

Moreno_2-mrn2222q9u976.pdf
Moreno_2-mrn2222q9u976.pdfGröße: 93.47 KBDownloads: 831

Datum

2019

Autor:innen

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-2-mrn2222q9u976
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.mad.2018.06.006
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Urheberrechtlich geschützt

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Mechanisms of Ageing and Development. 2019, 177, pp. 128-134. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2018.06.006

Zusammenfassung

Ageing is a multifactorial process that affects most, if not all, of the body’s tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that ‘biological age’ of a person may be different from ‘chronological age’. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Therefore, establishment of markers of biological ageing is important for preventing age-associated diseases and extending health span. MARK-AGE, a large-scale European study, aimed at identifying a set of biomarkers which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. But beyond the identification of useful biomarkers, MARK-AGE provided new insights in age-associated specific cellular processes, such as DNA methylation, oxidative stress and the regulation of zinc homeostasis.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Human ageing, Biomarkers, Chronological age, Biological age, Health span, Observational study, Europe, Nutrition, Peripheral blood mononuclear cells, DNA damage, Epigenetics, Oxidative stress, Zinc homeostasis, DNA methyltransferases, en-eleven translocation family of 5-mC hydroxylases, Vaccination

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690MORENO-VILLANUEVA, Maria, Alexander BÜRKLE, 2019. Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study. In: Mechanisms of Ageing and Development. 2019, 177, pp. 128-134. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2018.06.006
BibTex
@article{MorenoVillanueva2019Epige-45053,
  year={2019},
  doi={10.1016/j.mad.2018.06.006},
  title={Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study},
  volume={177},
  issn={0047-6374},
  journal={Mechanisms of Ageing and Development},
  pages={128--134},
  author={Moreno-Villanueva, Maria and Bürkle, Alexander}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/45053">
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/45053"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:issued>2019</dcterms:issued>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Bürkle, Alexander</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-02-15T09:42:09Z</dc:date>
    <dc:rights>terms-of-use</dc:rights>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/45053/1/Moreno_2-mrn2222q9u976.pdf"/>
    <dcterms:abstract xml:lang="eng">Ageing is a multifactorial process that affects most, if not all, of the body’s tissues and organs and can be defined as the accumulation of physical and psychological changes in a human being over time. The rate of ageing differs between individuals of the same chronological age, meaning that ‘biological age’ of a person may be different from ‘chronological age’. Furthermore, ageing represents a very potent risk factor for diseases and disability in humans. Therefore, establishment of markers of biological ageing is important for preventing age-associated diseases and extending health span. MARK-AGE, a large-scale European study, aimed at identifying a set of biomarkers which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. But beyond the identification of useful biomarkers, MARK-AGE provided new insights in age-associated specific cellular processes, such as DNA methylation, oxidative stress and the regulation of zinc homeostasis.</dcterms:abstract>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-02-15T09:42:09Z</dcterms:available>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Bürkle, Alexander</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <dc:contributor>Moreno-Villanueva, Maria</dc:contributor>
    <dc:creator>Moreno-Villanueva, Maria</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:title>Epigenetic and redox biomarkers : Novel insights from the MARK-AGE study</dcterms:title>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/45053/1/Moreno_2-mrn2222q9u976.pdf"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen