Publikation: Metabolism and requirement of Vitamin-E
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Alpha-tocopherol (vitamin E), the main lipid-soluble antioxidant in biological membranes, reacts readily with radical and non-radical oxidants. Such reactions may lead to alpha-tocopherol consumption, defined as loss of antioxidant action. Irreversibly oxidized metabolites excreted via the bile into the feces are tocopheryl quinone, epoxyquinones, and products of dimeric and trimeric structures. A alpha-tocopherol balance cannot be calculated, due to low intestinal absorption, enterohepatic circulation, and microbial metabolism in the intestine. For these reasons physiological vitamin E requirement cannot be derived from the alpha-tocopherol turnover. A common approach towards dietary recommendations is based on the PUFA - vitamin E relationship. Recently it was discovered that not the Simon metabolites, but 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxy-chroman (alpha-CEHC) is the major urinary excretion product. Our finding that excretion of this metabolite depends on the plasma tocopherol concentration has been reason to conclude that alpha-CEHC may be a marker of the optimum prophylactic vitamin E intake.
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GASSMANN, Berthold, Manfred SCHULTZ, Marcel LEIST, Regina BRIGELIUS-FLOHÉ, 1995. Metabolism and requirement of Vitamin-E. In: Ernährungs-Umschau : Forschung & Praxis. Umschau-Zeitschriftenverlag. 1995, 42(3), pp. 80. ISSN 0174-0008BibTex
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<dcterms:abstract xml:lang="eng">Alpha-tocopherol (vitamin E), the main lipid-soluble antioxidant in biological membranes, reacts readily with radical and non-radical oxidants. Such reactions may lead to alpha-tocopherol consumption, defined as loss of antioxidant action. Irreversibly oxidized metabolites excreted via the bile into the feces are tocopheryl quinone, epoxyquinones, and products of dimeric and trimeric structures. A alpha-tocopherol balance cannot be calculated, due to low intestinal absorption, enterohepatic circulation, and microbial metabolism in the intestine. For these reasons physiological vitamin E requirement cannot be derived from the alpha-tocopherol turnover. A common approach towards dietary recommendations is based on the PUFA - vitamin E relationship. Recently it was discovered that not the Simon metabolites, but 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxy-chroman (alpha-CEHC) is the major urinary excretion product. Our finding that excretion of this metabolite depends on the plasma tocopherol concentration has been reason to conclude that alpha-CEHC may be a marker of the optimum prophylactic vitamin E intake.</dcterms:abstract>
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