Publikation:

D-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis

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Fittipaldi_IAI_2008.pdf
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Datum

2008

Autor:innen

Fittipaldi, Nahuel
Sekizaki, Tsutomu
Takamatsu, Daisuke
Harel, Josée
Cruz Domínguez-Punaro, María de la
Draing, Christian
Marois, Corinne
Kobisch, Marylène
Gottschalk, Marcelo

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-75668
DOI (zitierfähiger Link)
https://doi.org/10.1128/IAI.01568-07
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Published

Erschienen in

Infection and immunity. 2008, 76(8), pp. 3587-3594. ISSN 0019-9567. eISSN 1098-5522. Available under: doi: 10.1128/IAI.01568-07

Zusammenfassung

We generated by allelic replacement a Delta dlt A mutant of a virulent Streptococcus suis serotype 2 field strain and evaluated the contribution of lipoteichoic acid (LTA) D-alanylation to the virulence traits of this swine pathogen and zoonotic agent. The absence of LTA D-alanylation resulted in increased susceptibility to the action of cationic antimicrobial peptides. In addition, and in contrast to the wild-type strain, the Delta dltA mutant was efficiently killed by porcine neutrophils and showed diminished adherence to and invasion of porcine brain microvascular endothelial cells. Finally, the Delta dltA mutant was attenuated in both the CD1 mouse and porcine models of infection, probably reflecting a decreased ability to escape immune clearance mechanisms and an impaired capacity to move across host barriers. The results of this study suggest that LTA D-alanylation is an important factor in S. suis virulence.

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570 Biowissenschaften, Biologie

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ISO 690FITTIPALDI, Nahuel, Tsutomu SEKIZAKI, Daisuke TAKAMATSU, Josée HAREL, María de la CRUZ DOMÍNGUEZ-PUNARO, Sonja von AULOCK, Christian DRAING, Corinne MAROIS, Marylène KOBISCH, Marcelo GOTTSCHALK, 2008. D-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis. In: Infection and immunity. 2008, 76(8), pp. 3587-3594. ISSN 0019-9567. eISSN 1098-5522. Available under: doi: 10.1128/IAI.01568-07
BibTex
@article{Fittipaldi2008DAlan-6568,
  year={2008},
  doi={10.1128/IAI.01568-07},
  title={D-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis},
  number={8},
  volume={76},
  issn={0019-9567},
  journal={Infection and immunity},
  pages={3587--3594},
  author={Fittipaldi, Nahuel and Sekizaki, Tsutomu and Takamatsu, Daisuke and Harel, Josée and Cruz Domínguez-Punaro, María de la and Aulock, Sonja von and Draing, Christian and Marois, Corinne and Kobisch, Marylène and Gottschalk, Marcelo}
}
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