Publikation: The integration of signaling and the spatial organization of the T cell synapse
Lade...
Dateien
Datum
2012
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Gold
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Frontiers in Immunology. 2012, 3, 352. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2012.00352
Zusammenfassung
Engagement of the T cell antigen receptor (TCR) triggers signaling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor molecules, dimers, oligomers and higher order structures. Here we discuss recent findings and new concepts that may regulate TCR organization in naïve and memory T cells. A key question that has emerged is how antigen-TCR interactions encode spatial information to direct T cell activation and differentiation. Single molecule super-resolution microscopy may become an important tool in decoding receptor organization at the molecular level.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
T cell receptor, membrane organization, receptor oligomerization, signaling assembly, T cell activation
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
ROSSY, Jérémie, David J. WILLIAMSON, Carola BENZING, Katharina GAUS, 2012. The integration of signaling and the spatial organization of the T cell synapse. In: Frontiers in Immunology. 2012, 3, 352. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2012.00352BibTex
@article{Rossy2012integ-43159,
year={2012},
doi={10.3389/fimmu.2012.00352},
title={The integration of signaling and the spatial organization of the T cell synapse},
volume={3},
journal={Frontiers in Immunology},
author={Rossy, Jérémie and Williamson, David J. and Benzing, Carola and Gaus, Katharina},
note={Article Number: 352}
}RDF
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bibo="http://purl.org/ontology/bibo/"
xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:void="http://rdfs.org/ns/void#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#" >
<rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43159">
<dc:rights>Attribution 3.0 Unported</dc:rights>
<dcterms:title>The integration of signaling and the spatial organization of the T cell synapse</dcterms:title>
<dcterms:abstract xml:lang="eng">Engagement of the T cell antigen receptor (TCR) triggers signaling pathways that lead to T cell selection, differentiation and clonal expansion. Superimposed onto the biochemical network is a spatial organization that describes individual receptor molecules, dimers, oligomers and higher order structures. Here we discuss recent findings and new concepts that may regulate TCR organization in naïve and memory T cells. A key question that has emerged is how antigen-TCR interactions encode spatial information to direct T cell activation and differentiation. Single molecule super-resolution microscopy may become an important tool in decoding receptor organization at the molecular level.</dcterms:abstract>
<void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
<dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/43159/1/Rossy_2-lq6isofli7es3.pdf"/>
<dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/3.0/"/>
<dc:contributor>Benzing, Carola</dc:contributor>
<dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-08-30T14:10:50Z</dc:date>
<dc:creator>Rossy, Jérémie</dc:creator>
<foaf:homepage rdf:resource="http://localhost:8080/"/>
<dc:contributor>Rossy, Jérémie</dc:contributor>
<dc:contributor>Williamson, David J.</dc:contributor>
<dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/43159/1/Rossy_2-lq6isofli7es3.pdf"/>
<dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-08-30T14:10:50Z</dcterms:available>
<dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:language>eng</dc:language>
<dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
<dc:creator>Williamson, David J.</dc:creator>
<dc:contributor>Gaus, Katharina</dc:contributor>
<dc:creator>Gaus, Katharina</dc:creator>
<bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/43159"/>
<dc:creator>Benzing, Carola</dc:creator>
<dcterms:issued>2012</dcterms:issued>
</rdf:Description>
</rdf:RDF>Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Begutachtet
Ja
