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Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing

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2025

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Institutionen der Bundesrepublik Deutschland: 161L0243B
Institutionen der Bundesrepublik Deutschland: 016LW0146K
European Union (EU): 964537
European Union (EU): 964518
European Union (EU): 101057014

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Alternatives to Animal Experimentation : ALTEX. Springer. ISSN 1868-596X. eISSN 1868-8551. Verfügbar unter: doi: 10.14573/altex.2501091

Zusammenfassung

On occasion of the DNT5 meeting in Konstanz, Germany (April-2024), participants brainstormed on future challenges concerning a regulatory implementation of the developmental neurotoxicity (DNT) in vitro test battery (DNT-IVB). The five discussion topics below outline some of the key issues, opportunities and research directions for the next several years: (1) How to contextualize DNT hazard with information on potential maternal toxicity or other toxicity domains (non-DNT)? Several approaches on how to use cytotoxicity data from NAMs were discussed. (2) What opportunities exist for an immediate or near-future application of the DNT-IVB, e.g. as a prioritisation step or add-on to other information? Initial examples are already emerging; the data can be used even if the battery is not converted to a defined approach. (3) How to establish data interpretation procedures for multi-dimensional endpoints that reduce dimensionality and are suitable for classification? A decision framework is required on how to use the DNT-IVB in a regulatory context. Machine-learning (AI-approaches) may provide novel classification models. (4) How can a battery of molecular initiating events (MIEs) be smartly linked to the DNT-IVB? If decisions are required, at what tier of an overall strategy would MIEs be evaluated, and how would optimally balance cost vs information yield. (5) What is the way forward to scientific validation of DNT NAMs and the DNT-IVB? A large set of animal data would be required for conventional approaches, while mechanistic information may establish relevance in other ways.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

DNT in vitro test battery (DNT-IVB), new approach methodologies (NAMs), key neurodevelopmental processes (KNDP), adverse outcome pathways (AOP), cytotoxicity, screening, physiologically-based kinetic modelling (PBK), next generation risk assessement (NGRA)

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ISO 690CÖLLEN, Eike, Jonathan BLUM, Ivana CELARDO, Nadine DRESER, Thomas HARTUNG, Viktoria MAGEL, Giorgia PALLOCCA, Costanza ROVIDA, Ilinca SUCIU, Yaroslav TANASKOV, Silvia TANGIANU, Chiara WOLFBEISZ, Marcel LEIST, 2025. Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing. In: Alternatives to Animal Experimentation : ALTEX. Springer. ISSN 1868-596X. eISSN 1868-8551. Verfügbar unter: doi: 10.14573/altex.2501091
BibTex
@article{Collen2025Mappi-72072,
  title={Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing},
  year={2025},
  doi={10.14573/altex.2501091},
  issn={1868-596X},
  journal={Alternatives to Animal Experimentation : ALTEX},
  author={Cöllen, Eike and Blum, Jonathan and Celardo, Ivana and Dreser, Nadine and Hartung, Thomas and Magel, Viktoria and Pallocca, Giorgia and Rovida, Costanza and Suciu, Ilinca and Tanaskov, Yaroslav and Tangianu, Silvia and Wolfbeisz, Chiara and Leist, Marcel}
}
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