Publikation: Protein degrons and degradation : Exploring substrate recognition and pathway selection in plants
Dateien
Datum
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
Internationale Patentnummer
Angaben zur Forschungsförderung
National Natural Science Foundation of China: 32222087
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Publikationsstatus
Erschienen in
Zusammenfassung
Proteome composition is dynamic and influenced by many internal and external cues, including developmental signals, light availability, or environmental stresses. Protein degradation, in synergy with protein biosynthesis, allows cells to respond to various stimuli and adapt by reshaping the proteome. Protein degradation mediates the final and irreversible disassembly of proteins, which is important for protein quality control and to eliminate misfolded or damaged proteins, as well as entire organelles. Consequently, it contributes to cell resilience by buffering against protein or organellar damage caused by stresses. Moreover, protein degradation plays important roles in cell signaling, as well as transcriptional and translational events. The intricate task of recognizing specific proteins for degradation is achieved by specialized systems that are tailored to the substrate's physicochemical properties and subcellular localization. These systems recognize diverse substrate cues collectively referred to as “degrons,” which can assume a range of configurations. They are molecular surfaces recognized by E3 ligases of the ubiquitin-proteasome system but can also be considered as general features recognized by other degradation systems, including autophagy or even organellar proteases. Here we provide an overview of the newest developments in the field, delving into the intricate processes of protein recognition and elucidating the pathways through which they are recruited for degradation.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
Schlagwörter
Konferenz
Rezension
Zitieren
ISO 690
ISONO, Erika, Jianming LI, Pablo PULIDO, Wei SIAO, Steven H SPOEL, Zhishuo WANG, Xiaohong ZHUANG, Marco TRUJILLO, 2024. Protein degrons and degradation : Exploring substrate recognition and pathway selection in plants. In: The Plant Cell. Oxford University Press (OUP). 2024, 36(9), S. 3074-3098. ISSN 1040-4651. eISSN 1532-298X. Verfügbar unter: doi: 10.1093/plcell/koae141BibTex
@article{Isono2024-09-03Prote-70191, year={2024}, doi={10.1093/plcell/koae141}, title={Protein degrons and degradation : Exploring substrate recognition and pathway selection in plants}, number={9}, volume={36}, issn={1040-4651}, journal={The Plant Cell}, pages={3074--3098}, author={Isono, Erika and Li, Jianming and Pulido, Pablo and Siao, Wei and Spoel, Steven H and Wang, Zhishuo and Zhuang, Xiaohong and Trujillo, Marco}, note={Article Number: e14627} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/70191"> <dc:contributor>Li, Jianming</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2024-06-20T11:16:47Z</dc:date> <dc:contributor>Siao, Wei</dc:contributor> <dc:creator>Siao, Wei</dc:creator> <dc:contributor>Zhuang, Xiaohong</dc:contributor> <dc:contributor>Spoel, Steven H</dc:contributor> <dc:contributor>Trujillo, Marco</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2024-06-20T11:16:47Z</dcterms:available> <dc:language>eng</dc:language> <dc:creator>Li, Jianming</dc:creator> <dcterms:title>Protein degrons and degradation : Exploring substrate recognition and pathway selection in plants</dcterms:title> <dc:creator>Pulido, Pablo</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Wang, Zhishuo</dc:contributor> <dc:creator>Isono, Erika</dc:creator> <dc:creator>Spoel, Steven H</dc:creator> <dc:contributor>Pulido, Pablo</dc:contributor> <dc:creator>Trujillo, Marco</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dc:contributor>Isono, Erika</dc:contributor> <dc:creator>Zhuang, Xiaohong</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:issued>2024-09-03</dcterms:issued> <dc:creator>Wang, Zhishuo</dc:creator> <dcterms:abstract>Proteome composition is dynamic and influenced by many internal and external cues, including developmental signals, light availability, or environmental stresses. Protein degradation, in synergy with protein biosynthesis, allows cells to respond to various stimuli and adapt by reshaping the proteome. Protein degradation mediates the final and irreversible disassembly of proteins, which is important for protein quality control and to eliminate misfolded or damaged proteins, as well as entire organelles. Consequently, it contributes to cell resilience by buffering against protein or organellar damage caused by stresses. Moreover, protein degradation plays important roles in cell signaling, as well as transcriptional and translational events. The intricate task of recognizing specific proteins for degradation is achieved by specialized systems that are tailored to the substrate's physicochemical properties and subcellular localization. These systems recognize diverse substrate cues collectively referred to as “degrons,” which can assume a range of configurations. They are molecular surfaces recognized by E3 ligases of the ubiquitin-proteasome system but can also be considered as general features recognized by other degradation systems, including autophagy or even organellar proteases. Here we provide an overview of the newest developments in the field, delving into the intricate processes of protein recognition and elucidating the pathways through which they are recruited for degradation.</dcterms:abstract> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/70191"/> </rdf:Description> </rdf:RDF>