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Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge

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2021

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Zwicker, Felix
Huber, Peter E.
Debus, Jürgen

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Anticancer research. Stanford University Highwire Press. 2021, 41(4), pp. 1909-1920. ISSN 0250-7005. eISSN 1791-7530. Available under: doi: 10.21873/anticanres.14957

Zusammenfassung

This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined.Background/Aim: This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined. Patients and Methods: For 10 patients with left-sided breast cancer each four helical IMRT-plans with TomoEdge-technique were created: hypofractionated+SIB (H-SIB) (42.4/54.4 Gy, 16 fractions), normofractionated+SIB (N-SIB) (50.4/64.4 Gy, 28 fractions), hypofractionated+sequential-boost (H-SB) (42.4 Gy/16 fractions+16 Gy/8 fractions), normofractionated+ sequential-boost (N-SB) (50.4 Gy/28 fractions+16 Gy/8 fractions). Equivalent doses (EQD2) to organs-at-risk (OAR) and irradiated mammary-gland were analysed for different assumed α/β-values. Results: The mean EQD2 to OAR was significantly lower using hypofractionated radiation-techniques. H-SIB and H-SB were not significantly different. H-SIB and N-SIB conformed significantly better to the breast planning-target volume (PTV) and boost-volume (BV) than H-SB and N-SB. Regarding BV, mean EQD2 was significantly higher for all α/β-values investigated when using H-SIB and N-SIB. Regarding PTV, there were no clinically relevant differences. Conclusion: Relating to dosimetry, H-SIB is effective compared to standard-boost-techniques.

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610 Medizin

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Hypofractionated radiotherapy, simultaneous integrated boost, SIB, breast cancer, helical tomotherapy, TomoEdge, IMRT

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ISO 690ZWICKER, Felix, Sebastian HÖFEL, Corinna KIRCHNER, Peter E. HUBER, Jürgen DEBUS, Michael SCHEMPP, 2021. Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge. In: Anticancer research. Stanford University Highwire Press. 2021, 41(4), pp. 1909-1920. ISSN 0250-7005. eISSN 1791-7530. Available under: doi: 10.21873/anticanres.14957
BibTex
@article{Zwicker2021-04Hypof-53617,
  year={2021},
  doi={10.21873/anticanres.14957},
  title={Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge},
  number={4},
  volume={41},
  issn={0250-7005},
  journal={Anticancer research},
  pages={1909--1920},
  author={Zwicker, Felix and Höfel, Sebastian and Kirchner, Corinna and Huber, Peter E. and Debus, Jürgen and Schempp, Michael}
}
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