Publikation:

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

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gola_219823.pdf
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2013

Autor:innen

Engler, Harald
Kolassa, Stephan
Schedlowski, Manfred

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http://nbn-resolving.de/urn:nbn:de:bsz:352-219823
DOI (zitierfähiger Link)
https://doi.org/10.1186/1471-244X-13-40
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Open Access-Veröffentlichung
Open Access Gold

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Biologie: Publikationen
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Published

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BMC Psychiatry. 2013, 13(1), 40. eISSN 1471-244X. Available under: doi: 10.1186/1471-244X-13-40

Zusammenfassung

BACKGROUND
Posttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions. METHODS: We investigated plasma cytokine levels as well as spontaneous and lipopolysaccharide (LPS)-stimulated cytokine production by peripheral blood mononuclear cells (PBMCs) in a group of 35 severely traumatized PTSD patients compared to 25 healthy controls. RESULTS: Spontaneous production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha by isolated PBMCs was significantly higher in the PTSD compared to the control group and even correlated with PTSD symptom severity within the PTSD group. In contrast, circulating plasma levels of pro- and anti-inflammatory cytokines such as IL-6, IL-8, IL-10, TNF-alpha, or monocyte chemotactic protein (MCP)-1 were not significantly altered in PTSD patients compared to healthy controls.

CONCLUSIONS
Our findings indicate that PBMCs of PTSD patients are already pre-activated in vivo, providing further evidence for low-grade inflammation in PTSD. This might possibly represent one psychobiological pathway from PTSD to poor physical health.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Posttraumatic stress disorder, Immune system, Cytokines, Pro-inflammatory cytokines, Traumatic stress, Inflammation

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ISO 690GOLA, Hannah, Harald ENGLER, Annette SOMMERSHOF, Hannah ADENAUER, Stephan KOLASSA, Manfred SCHEDLOWSKI, Marcus GRÖTTRUP, Thomas ELBERT, Iris-Tatjana KOLASSA, 2013. Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. In: BMC Psychiatry. 2013, 13(1), 40. eISSN 1471-244X. Available under: doi: 10.1186/1471-244X-13-40
BibTex
@article{Gola2013Postt-21982,
  year={2013},
  doi={10.1186/1471-244X-13-40},
  title={Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells},
  number={1},
  volume={13},
  journal={BMC Psychiatry},
  author={Gola, Hannah and Engler, Harald and Sommershof, Annette and Adenauer, Hannah and Kolassa, Stephan and Schedlowski, Manfred and Gröttrup, Marcus and Elbert, Thomas and Kolassa, Iris-Tatjana},
  note={Article Number: 40}
}
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