Exploration of biological network centralities with CentiBiN

Lade...
Vorschaubild
Dateien
Junker_2-ko6buwe7n2670.pdf
Junker_2-ko6buwe7n2670.pdfGröße: 1.15 MBDownloads: 388
Datum
2006
Autor:innen
Junker, Björn H.
Koschützki, Dirk
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
EU-Projektnummer
DFG-Projektnummer
Angaben zur Forschungsförderung (Freitext)
Projekt
Open Access-Veröffentlichung
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
BMC Bioinformatics. 2006, 7, 219. eISSN 1471-2105. Available under: doi: 10.1186/1471-2105-7-219
Zusammenfassung

Background

The elucidation of whole-cell regulatory, metabolic, interaction and other biological networks generates the need for a meaningful ranking of network elements. Centrality analysis ranks network elements according to their importance within the network structure and different centrality measures focus on different importance concepts. Central elements of biological networks have been found to be, for example, essential for viability.

Results

CentiBiN (Cent ralities i n Bi ological N etworks) is a tool for the computation and exploration of centralities in biological networks such as protein-protein interaction networks. It computes 17 different centralities for directed or undirected networks, ranging from local measures, that is, measures that only consider the direct neighbourhood of a network element, to global measures. CentiBiN supports the exploration of the centrality distribution by visualising central elements within the network and provides several layout mechanisms for the automatic generation of graphical representations of a network. It supports different input formats, especially for biological networks, and the export of the computed centralities to other tools.

Conclusion

CentiBiN helps systems biology researchers to identify crucial elements of biological networks. CentiBiN including a user guide and example data sets is available free of charge at http://centibin.ipk-gatersleben.de/. CentiBiN is available in two different versions: a Java Web Start application and an installable Windows application.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
004 Informatik
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690JUNKER, Björn H., Dirk KOSCHÜTZKI, Falk SCHREIBER, 2006. Exploration of biological network centralities with CentiBiN. In: BMC Bioinformatics. 2006, 7, 219. eISSN 1471-2105. Available under: doi: 10.1186/1471-2105-7-219
BibTex
@article{Junker2006Explo-40458,
  year={2006},
  doi={10.1186/1471-2105-7-219},
  title={Exploration of biological network centralities with CentiBiN},
  volume={7},
  journal={BMC Bioinformatics},
  author={Junker, Björn H. and Koschützki, Dirk and Schreiber, Falk},
  note={Article Number: 219}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/40458">
    <dc:contributor>Koschützki, Dirk</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-10-30T13:19:30Z</dcterms:available>
    <dc:creator>Schreiber, Falk</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40458/1/Junker_2-ko6buwe7n2670.pdf"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Junker, Björn H.</dc:creator>
    <dc:contributor>Junker, Björn H.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40458/1/Junker_2-ko6buwe7n2670.pdf"/>
    <dc:language>eng</dc:language>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/40458"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
    <dcterms:title>Exploration of biological network centralities with CentiBiN</dcterms:title>
    <dcterms:issued>2006</dcterms:issued>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;&lt;br /&gt;The elucidation of whole-cell regulatory, metabolic, interaction and other biological networks generates the need for a meaningful ranking of network elements. Centrality analysis ranks network elements according to their importance within the network structure and different centrality measures focus on different importance concepts. Central elements of biological networks have been found to be, for example, essential for viability.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;&lt;br /&gt;CentiBiN (Cent ralities i n Bi ological N etworks) is a tool for the computation and exploration of centralities in biological networks such as protein-protein interaction networks. It computes 17 different centralities for directed or undirected networks, ranging from local measures, that is, measures that only consider the direct neighbourhood of a network element, to global measures. CentiBiN supports the exploration of the centrality distribution by visualising central elements within the network and provides several layout mechanisms for the automatic generation of graphical representations of a network. It supports different input formats, especially for biological networks, and the export of the computed centralities to other tools.&lt;br /&gt;&lt;br /&gt;Conclusion&lt;br /&gt;&lt;br /&gt;CentiBiN helps systems biology researchers to identify crucial elements of biological networks. CentiBiN including a user guide and example data sets is available free of charge at http://centibin.ipk-gatersleben.de/. CentiBiN is available in two different versions: a Java Web Start application and an installable Windows application.</dcterms:abstract>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/36"/>
    <dc:creator>Koschützki, Dirk</dc:creator>
    <dc:contributor>Schreiber, Falk</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-10-30T13:19:30Z</dc:date>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen