Publikation:

Exploration of biological network centralities with CentiBiN

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Junker_2-ko6buwe7n2670.pdf
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Datum

2006

Autor:innen

Junker, Björn H.
Koschützki, Dirk

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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-ko6buwe7n2670
DOI (zitierfähiger Link)
https://doi.org/10.1186/1471-2105-7-219
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Open Access Gold

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Published

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BMC Bioinformatics. 2006, 7, 219. eISSN 1471-2105. Available under: doi: 10.1186/1471-2105-7-219

Zusammenfassung

Background

The elucidation of whole-cell regulatory, metabolic, interaction and other biological networks generates the need for a meaningful ranking of network elements. Centrality analysis ranks network elements according to their importance within the network structure and different centrality measures focus on different importance concepts. Central elements of biological networks have been found to be, for example, essential for viability.

Results

CentiBiN (Cent ralities i n Bi ological N etworks) is a tool for the computation and exploration of centralities in biological networks such as protein-protein interaction networks. It computes 17 different centralities for directed or undirected networks, ranging from local measures, that is, measures that only consider the direct neighbourhood of a network element, to global measures. CentiBiN supports the exploration of the centrality distribution by visualising central elements within the network and provides several layout mechanisms for the automatic generation of graphical representations of a network. It supports different input formats, especially for biological networks, and the export of the computed centralities to other tools.

Conclusion

CentiBiN helps systems biology researchers to identify crucial elements of biological networks. CentiBiN including a user guide and example data sets is available free of charge at http://centibin.ipk-gatersleben.de/. CentiBiN is available in two different versions: a Java Web Start application and an installable Windows application.

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ISO 690JUNKER, Björn H., Dirk KOSCHÜTZKI, Falk SCHREIBER, 2006. Exploration of biological network centralities with CentiBiN. In: BMC Bioinformatics. 2006, 7, 219. eISSN 1471-2105. Available under: doi: 10.1186/1471-2105-7-219
BibTex
@article{Junker2006Explo-40458,
  year={2006},
  doi={10.1186/1471-2105-7-219},
  title={Exploration of biological network centralities with CentiBiN},
  volume={7},
  journal={BMC Bioinformatics},
  author={Junker, Björn H. and Koschützki, Dirk and Schreiber, Falk},
  note={Article Number: 219}
}
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