Impurity-free amorphous calcium carbonate, a preferential material for pharmaceutic and medical applications

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European Journal of Mineralogy. 2019, 31(2), pp. 231-236. ISSN 0935-1221. eISSN 1617-4011. Available under: doi: 10.1127/ejm/2019/0031-2831
Zusammenfassung

Biomedical applications of calcium carbonate minerals have been receiving an increasing amount of attention. With a simple chemical composition, low production cost, and ease to produce in large quantities, this non-toxic (bio)mineral has been used preferentially in the pharmaceutical industry as a diluent, bulking or coating agent. Recently, novel products have been developed and amorphous calcium carbonate was successfully used as a hybrid carrier for drugs, proteins and genes. It is obvious that any impurities might have adverse effects in any of the aforementioned applications. However, the synthesis of impurity-free amorphous calcium carbonate often proves to be challenging due to its instability and rapid transformation to crystalline phases. Herein, we describe a novel, simple and scalable protocol for the synthesis of such impurity-free amorphous calcium carbonate nanoparticles that is potentially invaluable for critical health applications, improving the applicability of amorphous calcium carbonates in pharmaceutical and medical domains.

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540 Chemie
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amorphous calcium carbonate, nanoparticles, impurity-free, synthesis, drug delivery
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ISO 690AVARO, Jonathan Thomas, Cristina RUIZ AGUDO, Eliane LANDWEHR, Karin HAUSER, Denis GEBAUER, 2019. Impurity-free amorphous calcium carbonate, a preferential material for pharmaceutic and medical applications. In: European Journal of Mineralogy. 2019, 31(2), pp. 231-236. ISSN 0935-1221. eISSN 1617-4011. Available under: doi: 10.1127/ejm/2019/0031-2831
BibTex
@article{Avaro2019-06-07Impur-45103,
  year={2019},
  doi={10.1127/ejm/2019/0031-2831},
  title={Impurity-free amorphous calcium carbonate, a preferential material for pharmaceutic and medical applications},
  url={https://pubs.geoscienceworld.org/eurjmin/article-abstract/568487/impurity-free-amorphous-calcium-carbonate-a?redirectedFrom=fulltext},
  number={2},
  volume={31},
  issn={0935-1221},
  journal={European Journal of Mineralogy},
  pages={231--236},
  author={Avaro, Jonathan Thomas and Ruiz Agudo, Cristina and Landwehr, Eliane and Hauser, Karin and Gebauer, Denis}
}
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