Publikation: Vms1: a Cytosolic CAT-Tailing Antagonist to Protect Mitochondria
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2018
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Trends in Cell Biology. 2018, 28(1), pp. 3-5. ISSN 0962-8924. eISSN 1879-3088. Available under: doi: 10.1016/j.tcb.2017.11.003
Zusammenfassung
In eukaryotes, a cytosolic ribosome quality control complex recycles erroneously stalled ribosomes and modifies faulty nascent chains by ubiquitination and by C-terminal Ala-and Thr-extension (CAT-tailing). Reported recently in Cell, Izawa et al. identify cytosolic Vms1 (VCP/Cdc48-associated mitochondrial dysfunction caused by imported CAT-tailed polypeptides) as an inhibitor of CAT-tailing, which prevents mitochondrial dysfunction caused by imported CAT-tailed polypeptides.
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570 Biowissenschaften, Biologie
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KREFT, Stefan G., Elke DEUERLING, 2018. Vms1: a Cytosolic CAT-Tailing Antagonist to Protect Mitochondria. In: Trends in Cell Biology. 2018, 28(1), pp. 3-5. ISSN 0962-8924. eISSN 1879-3088. Available under: doi: 10.1016/j.tcb.2017.11.003BibTex
@article{Kreft2018-01Cytos-40890,
year={2018},
doi={10.1016/j.tcb.2017.11.003},
title={Vms1: a Cytosolic CAT-Tailing Antagonist to Protect Mitochondria},
number={1},
volume={28},
issn={0962-8924},
journal={Trends in Cell Biology},
pages={3--5},
author={Kreft, Stefan G. and Deuerling, Elke}
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<dcterms:abstract xml:lang="eng">In eukaryotes, a cytosolic ribosome quality control complex recycles erroneously stalled ribosomes and modifies faulty nascent chains by ubiquitination and by C-terminal Ala-and Thr-extension (CAT-tailing). Reported recently in Cell, Izawa et al. identify cytosolic Vms1 (VCP/Cdc48-associated mitochondrial dysfunction caused by imported CAT-tailed polypeptides) as an inhibitor of CAT-tailing, which prevents mitochondrial dysfunction caused by imported CAT-tailed polypeptides.</dcterms:abstract>
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