Publikation:

Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme

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2006

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Weinheim : Wiley-VCH

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http://nbn-resolving.de/urn:nbn:de:bsz:352-150938
DOI (zitierfähiger Link)
https://doi.org/10.1002/anie.200600909
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Open Access-Veröffentlichung

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Chemie: Publikationen
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Published

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Angewandte Chemie International Edition. 2006, 45(35), pp. 5875-5878. ISSN 1433-7851. Available under: doi: 10.1002/anie.200600909

Zusammenfassung

Modular design of functional RNAs can be used to tailor molecular properties. Guanosine-rich sequences were introduced as switching devices for functional nucleic acids. TMPyP4 (see picture) was identified as the strongest ribozyme inhibitor known to date. When quadruplex-forming, G-rich sequences were attached to the ribozyme, the TMPyP4-mediated response was inverted from inhibition to activation of the ribozyme reaction.

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Fachgebiet (DDC)
540 Chemie

Schlagwörter

inhibitors, nucleic acids, porphyrinoids, riboswitches, ribozymes

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ISO 690WIELAND, Markus, Jörg S. HARTIG, 2006. Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme. Weinheim : Wiley-VCH. In: Angewandte Chemie International Edition. 2006, 45(35), pp. 5875-5878. ISSN 1433-7851. Available under: doi: 10.1002/anie.200600909
BibTex
@article{Wieland2006-09-04Turni-15093,
  year={2006},
  doi={10.1002/anie.200600909},
  title={Turning Inhibitors into Activators: A Guanine-Quadruplex-controlled Hammerhead Ribozyme},
  number={35},
  volume={45},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={5875--5878},
  author={Wieland, Markus and Hartig, Jörg S.}
}
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