Publikation:

Proteasomes in immune cells : more than peptide producers?

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Groettrup_opus-107485.pdf
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2010

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Kirk, Christopher J.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-107485
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https://doi.org/10.1038/nri2687
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Open Access Green

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Biologie: Publikationen
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Nature Reviews Immunology. 2010, 10(1), pp. 73-78. ISSN 1474-1733. eISSN 1474-1741. Available under: doi: 10.1038/nri2687

Zusammenfassung

When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for presentation on MHC class I molecules. In addition, cortical thymic epithelial cells selectively express a type of proteasome known as the thymoproteasome that is required for the positive selection of thymocytes. Here, we discuss how these specialized types of proteasome shape the T cell receptor repertoire of cytotoxic T lymphocytes and propose that immunoproteasomes have functions, in addition to antigen processing, that influence cytokine production and T cell differentiation, survival and function. We also discuss how inhibitors of immunoproteasomes can suppress undesired T cell responses in autoimmune diseases.

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570 Biowissenschaften, Biologie

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ISO 690GRÖTTRUP, Marcus, Christopher J. KIRK, Michael BASLER, 2010. Proteasomes in immune cells : more than peptide producers?. In: Nature Reviews Immunology. 2010, 10(1), pp. 73-78. ISSN 1474-1733. eISSN 1474-1741. Available under: doi: 10.1038/nri2687
BibTex
@article{Grottrup2010Prote-1161,
  year={2010},
  doi={10.1038/nri2687},
  title={Proteasomes in immune cells : more than peptide producers?},
  number={1},
  volume={10},
  issn={1474-1733},
  journal={Nature Reviews Immunology},
  pages={73--78},
  author={Gröttrup, Marcus and Kirk, Christopher J. and Basler, Michael}
}
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