Publikation:

Poly(ADP-ribose) polymerase activity in different pathologies : the link to inflammation and infarction

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2008_ExpGerontol43_605_Beneke.pdf
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2008

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-77311
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https://doi.org/10.1016/j.exger.2008.04.008
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Experimental Gerontology. 2008, 43(7), pp. 605-614. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2008.04.008

Zusammenfassung

DNA repair and aging are two phenomena closely connected to each other. The poly(ADP-ribosyl)ation reaction has been implicated in both of them. Poly(ADP-ribose) was originally discovered as an enzymatic reaction product after DNA damage. Soon it became evident that it is necessary for regulation of different repair pathways. Also, evidence accumulated that poly(ADP-ribose) formation capacity is at least correlated with the life span of mammalian species. As a NAD+-consuming process, poly(ADP-ribosyl)ation can lead to cell death by energy depletion. This finding opened the area for investigation of poly(ADP-ribose) polymerase activity and polymer formation in pathologies. This review provides an introduction into the wide and complex field of poly(ADP-ribosyl)ation in different pathologies with regards of cell death regulation, inflammation and resulting tissue damage.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Poly(ADP-ribose) polymerase, Inflammation, NFjB, Ischemia reperfusion injury, Cell death, Reactive oxygen species

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ISO 690BENEKE, Sascha, 2008. Poly(ADP-ribose) polymerase activity in different pathologies : the link to inflammation and infarction. In: Experimental Gerontology. 2008, 43(7), pp. 605-614. ISSN 0531-5565. Available under: doi: 10.1016/j.exger.2008.04.008
BibTex
@article{Beneke2008PolyA-7387,
  year={2008},
  doi={10.1016/j.exger.2008.04.008},
  title={Poly(ADP-ribose) polymerase activity in different pathologies : the link to inflammation and infarction},
  number={7},
  volume={43},
  issn={0531-5565},
  journal={Experimental Gerontology},
  pages={605--614},
  author={Beneke, Sascha}
}
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