Publikation:

Altered oscillatory brain dynamics after repeated traumatic stress

Lade...
Vorschaubild

Dateien

1471_244X_7_56_2.pdf
1471_244X_7_56_2.pdfGröße: 592.28 KBDownloads: 299

Datum

2007

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Stress and trauma-associated immunological changes and their implications on health
Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

BMC Psychiatry. 2007, 7(1), 56. eISSN 1471-244X. Available under: doi: 10.1186/1471-244X-7-56

Zusammenfassung

Background:
Repeated traumatic experiences, e.g. torture and war, lead to functional and structural cerebral changes, which should be detectable in cortical dynamics. Abnormal slow waves produced within circumscribed brain regions during a resting state have been associated with lesioned neural circuitry in neurological disorders and more recently also in mental illness.
Methods

Using magnetoencephalographic (MEG-based) source imaging, we mapped abnormal distributions of generators of slow waves in 97 survivors of torture and war with posttraumatic stress disorder (PTSD) in comparison to 97 controls.

Results:
PTSD patients showed elevated production of focally generated slow waves (1 4 Hz), particularly in left temporal brain regions, with peak activities in the region of the insula. Furthermore, differential slow wave activity in right frontal areas was found in PTSD patients compared to controls.

Conclusion:
The insula, as a site of multimodal convergence, could play a key role in understanding the pathophysiology of PTSD, possibly accounting for what has been called posttraumatic alexithymia, i.e., reduced ability to identify, express and regulate emotional responses to reminders of traumatic events. Differences in activity in right frontal areas may indicate a dysfunctional PFC, which may lead to diminished extinction of conditioned fear and reduced inhibition of the amygdala.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690KOLASSA, Iris-Tatjana, Christian WIENBRUCH, Frank NEUNER, Maggie SCHAUER, Martina RUF-LEUSCHNER, Michael ODENWALD, Thomas ELBERT, 2007. Altered oscillatory brain dynamics after repeated traumatic stress. In: BMC Psychiatry. 2007, 7(1), 56. eISSN 1471-244X. Available under: doi: 10.1186/1471-244X-7-56
BibTex
@article{Kolassa2007Alter-11257,
  year={2007},
  doi={10.1186/1471-244X-7-56},
  title={Altered oscillatory brain dynamics after repeated traumatic stress},
  number={1},
  volume={7},
  journal={BMC Psychiatry},
  author={Kolassa, Iris-Tatjana and Wienbruch, Christian and Neuner, Frank and Schauer, Maggie and Ruf-Leuschner, Martina and Odenwald, Michael and Elbert, Thomas},
  note={Article Number: 56}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/11257">
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dc:contributor>Wienbruch, Christian</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dc:language>eng</dc:language>
    <dc:contributor>Odenwald, Michael</dc:contributor>
    <dc:creator>Odenwald, Michael</dc:creator>
    <dc:contributor>Schauer, Maggie</dc:contributor>
    <dc:contributor>Ruf-Leuschner, Martina</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/11257/1/1471_244X_7_56_2.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Neuner, Frank</dc:creator>
    <dc:creator>Wienbruch, Christian</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Kolassa, Iris-Tatjana</dc:creator>
    <dcterms:issued>2007</dcterms:issued>
    <dcterms:bibliographicCitation>First publ. in: BMC Psychiatry ; 7 (2007). - 56</dcterms:bibliographicCitation>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/11257/1/1471_244X_7_56_2.pdf"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Kolassa, Iris-Tatjana</dc:contributor>
    <dc:creator>Ruf-Leuschner, Martina</dc:creator>
    <dc:creator>Schauer, Maggie</dc:creator>
    <dc:contributor>Elbert, Thomas</dc:contributor>
    <dc:creator>Elbert, Thomas</dc:creator>
    <dc:format>application/pdf</dc:format>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/11257"/>
    <dcterms:title>Altered oscillatory brain dynamics after repeated traumatic stress</dcterms:title>
    <dc:contributor>Neuner, Frank</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-25T09:26:44Z</dcterms:available>
    <dcterms:abstract xml:lang="eng">Background:&lt;br /&gt;Repeated traumatic experiences, e.g. torture and war, lead to functional and structural cerebral changes, which should be detectable in cortical dynamics. Abnormal slow waves produced within circumscribed brain regions during a resting state have been associated with lesioned neural circuitry in neurological disorders and more recently also in mental illness.&lt;br /&gt;Methods&lt;br /&gt;&lt;br /&gt;Using magnetoencephalographic (MEG-based) source imaging, we mapped abnormal distributions of generators of slow waves in 97 survivors of torture and war with posttraumatic stress disorder (PTSD) in comparison to 97 controls.&lt;br /&gt;&lt;br /&gt;Results:&lt;br /&gt;PTSD patients showed elevated production of focally generated slow waves (1 4 Hz), particularly in left temporal brain regions, with peak activities in the region of the insula. Furthermore, differential slow wave activity in right frontal areas was found in PTSD patients compared to controls.&lt;br /&gt;&lt;br /&gt;Conclusion:&lt;br /&gt;The insula, as a site of multimodal convergence, could play a key role in understanding the pathophysiology of PTSD, possibly accounting for what has been called posttraumatic alexithymia, i.e., reduced ability to identify, express and regulate emotional responses to reminders of traumatic events. Differences in activity in right frontal areas may indicate a dysfunctional PFC, which may lead to diminished extinction of conditioned fear and reduced inhibition of the amygdala.</dcterms:abstract>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-25T09:26:44Z</dc:date>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen