Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent

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2022
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Dong, Liang
Xu, Yun-Jun
Sui, Cong
Zhao, Yang
Lu, Yang
Yu, Shu-Hong
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Amorphous calcium carbonate plays a key role as transient precursor in the early stages of biogenic calcium carbonate formation in nature. However, due to its instability in aqueous solution, there is still rare success to utilize amorphous calcium carbonate in biomedicine. Here, we report the mutual effect between paramagnetic gadolinium ions and amorphous calcium carbonate, resulting in ultrafine paramagnetic amorphous carbonate nanoclusters in the presence of both gadolinium occluded highly hydrated carbonate-like environment and poly(acrylic acid). Gadolinium is confirmed to enhance the water content in amorphous calcium carbonate, and the high water content of amorphous carbonate nanoclusters contributes to the much enhanced magnetic resonance imaging contrast efficiency compared with commercially available gadolinium-based contrast agents. Furthermore, the enhanced T1 weighted magnetic resonance imaging performance and biocompatibility of amorphous carbonate nanoclusters are further evaluated in various animals including rat, rabbit and beagle dog, in combination with promising safety in vivo. Overall, exceptionally facile mass-productive amorphous carbonate nanoclusters exhibit superb imaging performance and impressive stability, which provides a promising strategy to design magnetic resonance contrast agent.

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ISO 690DONG, Liang, Yun-Jun XU, Cong SUI, Yang ZHAO, Denis GEBAUER, Rose ROSENBERG, Jonathan Thomas AVARO, Yang LU, Helmut CÖLFEN, Shu-Hong YU, 2022. Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent. In: Nature Communications. Nature Publishing Group. 2022, 13(1), 5088. eISSN 2041-1723. Available under: doi: 10.1038/s41467-022-32615-3
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@article{Dong2022-08-29Highl-58488,
  year={2022},
  doi={10.1038/s41467-022-32615-3},
  title={Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent},
  number={1},
  volume={13},
  journal={Nature Communications},
  author={Dong, Liang and Xu, Yun-Jun and Sui, Cong and Zhao, Yang and Gebauer, Denis and Rosenberg, Rose and Avaro, Jonathan Thomas and Lu, Yang and Cölfen, Helmut and Yu, Shu-Hong},
  note={Article Number: 5088}
}
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