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Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients

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Fehr_biolpsych2001.pdf
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2001

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Biological psychiatry. 2001, 50, pp. 108-116. Available under: doi: 10.1016/S0006-3223(01)01122-2

Zusammenfassung

Background: Schizophrenic patients exhibit more activity
in the electroencephalographic delta and theta frequency
range than do control subjects. Using magnetic source
imaging (MSI) our study aimed to explore this phenomenon
in the magnetoencephalogram (MEG), the distribution
of its sources, and associations between symptom
profiles and sources of low-frequency activity in the brain.
Methods: Whole-head MEG recordings were obtained
from 28 schizophrenic patients and 20 healthy control
subjects during a resting condition. The generators of the
focal magnetic slow waves were located employing a
single moving dipole model. Distributed or multiple delta
and theta sources were captured by the minimum norm
estimate.
Results: Both localization procedures showed slow wave
activity to be enhanced in schizophrenic patients compared
with control subjects. Focal slow wave activity
differed most between groups in frontotemporal and in
posterior regions. Slow wave activity was associated with
symptom characteristics in that positive symptoms varied
with frontal delta and theta activity.
Conclusions: Results indicate that activity in low-frequency
bands in schizophrenic patients exceeds the activity
of control subjects in distinct areas, and that this focal
clustering of neuromagnetic slow waves may be related to psychopathologic characteristics.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

Schizophrenia, magnetoencephalography, slow waves, delta, theta, dipole modeling

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ISO 690FEHR, Thorsten, Johanna KISSLER, Stephan MORATTI, Christian WIENBRUCH, Brigitte ROCKSTROH, Thomas ELBERT, 2001. Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients. In: Biological psychiatry. 2001, 50, pp. 108-116. Available under: doi: 10.1016/S0006-3223(01)01122-2
BibTex
@article{Fehr2001Sourc-10332,
  year={2001},
  doi={10.1016/S0006-3223(01)01122-2},
  title={Source Distribution of Neuromagnetic Slow Waves and MEG-Delta Activity in Schizophrenic Patients},
  volume={50},
  journal={Biological psychiatry},
  pages={108--116},
  author={Fehr, Thorsten and Kissler, Johanna and Moratti, Stephan and Wienbruch, Christian and Rockstroh, Brigitte and Elbert, Thomas}
}
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    <dcterms:abstract xml:lang="eng">Background: Schizophrenic patients exhibit more activity&lt;br /&gt;in the electroencephalographic delta and theta frequency&lt;br /&gt;range than do control subjects. Using magnetic source&lt;br /&gt;imaging (MSI) our study aimed to explore this phenomenon&lt;br /&gt;in the magnetoencephalogram (MEG), the distribution&lt;br /&gt;of its sources, and associations between symptom&lt;br /&gt;profiles and sources of low-frequency activity in the brain.&lt;br /&gt;Methods: Whole-head MEG recordings were obtained&lt;br /&gt;from 28 schizophrenic patients and 20 healthy control&lt;br /&gt;subjects during a resting condition. The generators of the&lt;br /&gt;focal magnetic slow waves were located employing a&lt;br /&gt;single moving dipole model. Distributed or multiple delta&lt;br /&gt;and theta sources were captured by the minimum norm&lt;br /&gt;estimate.&lt;br /&gt;Results: Both localization procedures showed slow wave&lt;br /&gt;activity to be enhanced in schizophrenic patients compared&lt;br /&gt;with control subjects. Focal slow wave activity&lt;br /&gt;differed most between groups in frontotemporal and in&lt;br /&gt;posterior regions. Slow wave activity was associated with&lt;br /&gt;symptom characteristics in that positive symptoms varied&lt;br /&gt;with frontal delta and theta activity.&lt;br /&gt;Conclusions: Results indicate that activity in low-frequency&lt;br /&gt;bands in schizophrenic patients exceeds the activity&lt;br /&gt;of control subjects in distinct areas, and that this focal&lt;br /&gt;clustering of neuromagnetic slow waves may be related to psychopathologic characteristics.</dcterms:abstract>
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